ABT29

Anti-Tensin-3 Antibody

from rabbit, purified by affinity chromatography

• Sinonimo/i: Tensin-3, Tensin-like SH2 domain-containing protein 1, Tumor endothelial marker 6
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Purificato mediante: affinity chromatography
• Reattività contro le specie: human
• tecniche: immunocytochemistry: suitable; western blot: suitable
• N° accesso NCBI: NP_073585
• N° accesso UniProt: Q68CZ2
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... TNS3(64759)

Descrizione

Descrizione generale

Tensin-3 is a member of the Tensin family of proteins that serve as a connection between the cytoskeleton and extracellular matrix. Because of this link, Tensin’s are commonly thought to regulate signaling for the shape of the cell and motility. Tensin-3 localizes in the cell cytoplasm and has been shown to be significantly decreased in many different human cancer cell lines. Higher expression levels of Tensin-3 were also found to be associated with longer survival. Tensin-3 has also been found to be highly expressed in functioning thyroid follicular adenomas while expression is significantly lower in non-functioning thyroid follicular adenomas, which seems to imply that Tensin-3 has an important role in basic thyroid function.

Immunogeno

KLH-conjugated linear peptide corresponding to human Tensin-3.

Applicazioni

Anti-Tensin-3 Antibody detects level of Tensin-3 & has been published & validated for use in WB & IC.

Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Tensin-3 in A431 cells.

Research Category
Cell Structure

Research Sub Category
ECM Proteins

Cytoskeleton

Qualità

Evaluated by Western Blot in human kidney tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Tensin-3 in 10 µg of human kidney tissue lysate.

Descrizione del bersaglio

~180 kDa observed.
The calculated molecular weight is 155 kDa, however Tensin-3 has been shown as a ~180 kDa band in western blots (Cui, Y., et al. (2004). Molecular Cancer Research. 2:225–232).
An uncharacterized band appears at ~22 kDa in some lysates.

Stato fisico

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

Control
Human kidney tissue lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable