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Key Documents

AB3096

Sigma-Aldrich

Anti-Orexin Antibody, Prepro

Chemicon®, from rabbit

Sinonimo/i:

Anti-NRCLP1, Anti-OX, Anti-PPOX

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Forma dell’anticorpo

affinity purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Purificato mediante

affinity chromatography

Reattività contro le specie

mouse, human, rat

Produttore/marchio commerciale

Chemicon®

tecniche

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... PPOX(5498)

Specificità

Mouse Prepro-Orexin. Several peptides associated with feeding behavior have been reported recently. Orexins (Orexin-A and Orexin-B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus (Sakurai et al. 1998). Orexin-A and Orexin-B are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Prepro-orexin is an 130 aa peptide with a putative 33 aa secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis (Sakurai et al. 1998). These neuropeptides bind and activate two closely related Orexin receptors--G protein coupled receptors (GPCRs) OX1R and OX2R.

Immunogeno

A 17 mer peptide (designated PPOXA11-A) mapping near the C-terminus of mouse prepro-Orexin.

Applicazioni

Anti-Orexin Antibody, Prepro is an antibody against Orexin for use in ELISA, IH & WB.
Research Category
Neuroscience
Research Sub Category
CNS Control of Metabolism

Circadian Rhythm & Sleep
Western blot: 1-10 μg/mL using Chemiluminescence technique

ELISA: 1:10,000 - 100,000

Immunohistochemistry: 2-20 μg/mL.

Optimal working dilutions must be determined by end user.

Stato fisico

Liquid in PBS with 0.1% BSA.

Stoccaggio e stabilità

Can be refrigerated at 2-8°C in undiluted aliquots for short term use. Maintain frozen at -20°C in undiluted aliquots for up to 12 months.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Exaggerated natriuresis during clamping of systemic NO supply in healthy young men.
Simonsen, JA; Rasmussen, MS; Vach, W; H?ilund-Carlsen, PF; Bie, P
Clinical Science (London, England : 1979) (1979)
Simona Tafuri et al.
Neuropeptides, 43(2), 73-80 (2009-03-03)
The hypothalamic peptide orexin A, deriving from the proteolytic cleavage of the precursor molecule prepro-orexin, has a wide range of physiological effects including the regulation of feeding behaviour, neuroendocrine functions, sleep-wake cycle, and energy homeostasis. Lowered excretion of orexin A
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The Journal of Comparative Neurology null
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Anatomical record (Hoboken, N.J. : 2007), 292(2), 202-206 (2008-12-18)
The hypothalamic peptide orexin A (oxA) binds specifically the G-protein-coupled orexin receptor 1 (ox1R). It is involved in many physiological functions including the regulation of food intake, sleep-wake cycle, arterial blood pressure, heart rate, and sexual behavior. The localization of

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