8.52082

Fmoc-Lys(ivDde)-OH

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

• Sinonimo/i: Fmoc-Lys(ivDde)-OH, N-α-Fmoc-N-ε-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-lysine
• Formula empirica (notazione di Hill): C₃₄H₄₂N₂O₆
• Numero CAS: 204777-78-6
• Peso molecolare: 574.71
• Numero MDL: MFCD01631658
• Codice UNSPSC: 12352209
• NACRES: NA.22

Proprietà

• product name: Fmoc-Lys(ivDde)-OH, Novabiochem^®
• Livello qualitativo: 200
• Nome Commerciale: Novabiochem^®
• Saggio: ≥85.0% (acidimetric); ≥97% (TLC); ≥99.0% (HPLC)
• Forma fisica: powder
• Impiego in reazioni chimiche: reaction type: Fmoc solid-phase peptide synthesis
• Produttore/marchio commerciale: Novabiochem^®
• applicazioni: peptide synthesis
• Gruppo funzionale: amine
• Temperatura di conservazione: -10 to -25°C

Descrizione

Descrizione generale

This orthogonally-protected lysine derivative is based on the hindered Dde variant ivDde. It has very similar chemical properties to Fmoc-Lys(Dde)-OH, except that the side-chain ivDde group is considerably more stable to piperidine than Dde, and is less prone to migrate from protected to unprotected lysine side-chains ^[1].When removing ivDde in the presence of allyl based protecting groups, allyl alcohol should be included in the deprotection solution to prevent reduction of the allyl group ^[2].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS


Literature references

^[1] S. R. Chhabra, et al. (1998) Tetrahedron Lett., 39, 1603.
^[2] B. Rohwedder, et al. (1998) Tetrahedron Lett., 39, 1175.
^[3] V. Wittmann & S. Seeberger (2000) Angew. Chem. Int. Ed. Engl., 39, 4348.

Applicazioni

• Fmoc Solid-Phase Peptide Synthesis of Human α-Calcitonin Gene-Related Peptide and Two Fluorescent Analogs: This study highlights the use of Fmoc-Lys(ivDde)-OH at residue 24 during the synthesis of human α-calcitonin gene-related peptide, demonstrating its utility in peptide labeling and fluorescence studies (M Fuente-Moreno et al., researchgate.net).

Linkage

Replaces: 04-12-1193

Risultati analitici

Color (visual): white to slightly yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(157B)): ≥ 97 %
Purity (TLC(CMA2)): ≥ 97 %
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 85.0 %
Water (K. F.): ≤ 1.00 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Note legali

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable