8.22288

Periodic acid

for synthesis

• Sinonimo/i: Periodic acid
• Formula empirica (notazione di Hill): H₅IO₆
• Numero CAS: 10450-60-9
• Peso molecolare: 227.94
• Numero MDL: MFCD00011344
• Codice UNSPSC: 12352301
• Numero indice EU: 233-937-0
• NACRES: NA.22

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98% (iodometric)
• Forma fisica: solid
• Impiego in reazioni chimiche: reagent type: oxidant
• pH: 1.2 (20 °C, 100 g/L in H₂O)
• Punto di fusione: 122 °C
• Solubilità: ethanol: soluble at 20 °C; water: soluble at 20 °C
• Densità bulk: 1400 kg/m³
• Temperatura di conservazione: 15-25°C
• InChI: 1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7); TWLXDPFBEPBAQB-UHFFFAOYSA-N

Descrizione

Applicazioni

Periodic acid can be used as a reagent for the oxidative cleavage of 1,2 diols to ketones or aldehydes, and epoxides to aldehydes. It is also used in the oxidative cleavage of various protecting groups such as acetonide, tetrahydropyranyl ether (THP), ethoxyethyl acetals, cyclic acetals, dithioacetals, and oxathioacetals.
It can also be used:

• In the selective N-nitrosation of secondary amines in the presence of sodium nitrite, and wet silica gel.
• As a stoichiometric oxidant with chromium (IV) acetate for the oxidation of tertiary C−H bonds to tertiary alcohols.
• In combination with chromium oxide to oxidize primary alcohols to carboxylic acids; alkylbenzenes to benzoic acids; and cyclic benzyl ethers to the corresponding lactones.
• In the iodination of bulky polyalkyl benzenes in the presence of iodine.
• In the oxidative coupling of polycyclic aromatic hydrocarbons in the presence of aqueous acetic acid.
• In the selective oxidation of sulfides to sulfoxides using FeCl₃ as a catalyst.

Risultati analitici

Assay (iodometric): ≥ 98.0 %
Melting range (lower value): ≥ 124 °C
Melting range (upper value): ≤ 129 °C

Informazioni sulla sicurezza

• Pittogrammi: GHS03,GHS05,GHS08,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H271 - H314 - H372 - H410
• Consigli di prudenza: P210 - P260 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Classi di pericolo: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1B - STOT RE 1 Oral
• Organi bersaglio: Thyroid
• Codice della classe di stoccaggio: 5.1A - Strongly oxidizing hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable