567727

D-erythro-Sphingosine-1-phosphate

A putative second messenger that mobilizes calcium from intracellular stores via an IP3-independent pathway.

• Sinonimo/i: D-erythro-Sphingosine-1-phosphate
• Formula empirica (notazione di Hill): C₁₈H₃₈NO₅P
• Numero CAS: 26993-30-6
• Peso molecolare: 379.47
• Numero MDL: MFCD00270077
• Codice UNSPSC: 12352211
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (TLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic)
• Colore: white
• Solubilità: methanol: 0.5 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: 1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1; DUYSYHSSBDVJSM-KRWOKUGFSA-N

Descrizione

Descrizione generale

A putative second messenger that mobilizes calcium from intracellular stores via an IP₃ independent pathway. Activates phospholipase D and inhibits chemotactic motility and invasiveness of tumor cells. Also stimulates growth of quiescent Swiss 3T3 fibroblasts.

A putative second messenger that mobilizes calcium from intracellular stores via an IP₃-independent pathway. Activates phospholipase D (PLD) and inhibits chemotactic motility and invasiveness of tumor cells. Also stimulates growth of quiescent Swiss/3T3 fibroblasts. Inhibits activation of caspases that cleave PARP and lamins during Fas- and ceramide-mediated apoptosis.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Mobilizes calcium from intracellular stores

Product does not compete with ATP.

Reversible: no

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Irritant (B)

Nota sulla preparazione

Slight warming and vortexing may be required.

Ricostituzione

Following reconstitution, aliquot and evaporate under a stream of nitrogen. Store at -20°C. Prior to use, dissolve in 4 mg/ml BSA solution with vortexing. Stock solutions are stable for up to 2 months at -20°C.

Altre note

Cuvillier, O., et al. 1998. J. Biol. Chem. 273, 2910.
Mattie, M., et al. 1994. J. Biol. Chem.269, 3181.
Olivera, A. and Spiegel, S. 1993. Nature365, 557.
Desai, N.N., et al. 1992. J. Biol. Chem.267, 23122.
Sadahira, Y., et al. 1992. Proc. Natl. Acad. Sci. USA89, 9686.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable