567300

SKF-525A, Hydrochloride

Cell permeable. Blocks glibenclamide-sensitive K⁺ channels. Inhibits neuronal nitric oxide synthase. Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system.

• Sinonimo/i: SKF-525A, Hydrochloride, Proadifen
• Formula empirica (notazione di Hill): C₂₃H₃₁NO₂ · xHCl
• Numero CAS: 62-68-0
• Peso molecolare: 353.50 (free base basis)
• Numero MDL: MFCD00055151
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (TLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic)
• Colore: white
• Solubilità: water: 20 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: 1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3;/h7-16H,4-6,17-19H2,1-3H3;1H; FHIKZROVIDCMJA-UHFFFAOYSA-N

Descrizione

Descrizione generale

Cell permeable. Blocks glibenclamide-sensitive K⁺ channels (IC₅₀ = 4.4 µM). Inhibits neuronal nitric oxide synthase (IC₅₀ = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P-450 system. Stimulates endothelial cell prostocyclin production while inhibiting platelet thromboxane synthesis. Potentiates the effect of many drugs in vivo.

Cell permeable. Blocks glibenclamide-sensitive K⁺ channels. Inhibits neuronal nitric oxide synthase (IC₅₀ = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system. Stimulates endothelial cell prostacyclin production while inhibiting platelet thromboxane synthesis. Potentiates the action of many drugs in vivo.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
nNOS

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 90 µM against neuronal nitric oxide synthase

Attenzione

Toxicity: Harmful (C)

Ricostituzione

Following reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.

Altre note

Hecker, M., et al. 1994. J. Neurochem. 62, 1524.
Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol.252, 117.
Khan, S., et al. 1993. Biochem. Pharmacol.45, 439.
Boeynaems, J.M., et al. 1986. Prostaglandins32, 145.
Lee, C.H., et al. 1976. J. Pharmacol. Exp. Ther.198, 347.
Grasdalen, J., et al. 1975. FEBS Lett.60, 240.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable