548000

1-Pyrrolidinecarbodithioic Acid, Ammonium Salt

Cell permeable. Inhibits the induction of NOS activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells.

• Sinonimo/i: 1-Pyrrolidinecarbodithioic Acid, Ammonium Salt, APDC, Ammonium Pyrrolidinedithiocarbamate, PDTC, NH₄
• Formula empirica (notazione di Hill): C₅H₁₂N₂S₂
• Numero CAS: 5108-96-3
• Peso molecolare: 164.29
• Numero MDL: MFCD00012720
• Codice UNSPSC: 12352106
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (titration)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic)
• Colore: white
• Solubilità: water: 1 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3; MDDIUTVUBYEEEM-UHFFFAOYSA-N

Descrizione

Descrizione generale

Cell permeable. Inhibits the induction of nitric oxide synthase activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells. Inhibits NF-κB activation and HIV replication in lymphocytes.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
Induction of nitric oxide synthase activity in rat alveolar macrophages

Product does not compete with ATP.

Reversible: no

Attenzione

Toxicity: Irritant (B)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 3 months at -20°C.







From Catalog:

Desc. Field- added "cell-permeable"

Altre note

Tsai, J.C., et al. 1996. J. Biol. Chem.271, 3667.
Pan, Z., et al. 1995. J. Biol. Chem.270, 7787.
Bessho, R., et al. 1994. Biochem. Pharmacol.48, 1883.
Sherman, M.P., et al. 1993. Biochem. Biophys. Res. Commun.191, 1301.
Schreck, R., et al. 1992. J. Exp. Med.175, 1181.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable