528208

Plasminogen Activator Inhibitor-1, Mutant

from Recombinant, ≥95% (SDS-PAGE), liquid, PAI-1 inhibitor, Calbiochem^®

• Sinonimo/i: PAI-1, Mutant
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• product name: Plasminogen Activator Inhibitor-1, Mutant, Human, Recombinant, The Plasminogen Activator Inhibitor-1, Mutant, Human, Recombinant controls the biological activity of Plasminogen Activator. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
• Livello qualitativo: 100
• Saggio: ≥95% (SDS-PAGE)
• Forma fisica: liquid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; avoid repeated freeze/thaw cycles
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −70°C

Descrizione

Descrizione generale

Highly purified preparation of an altered form of human PAI-1 containing four mutated amino acids. Mutant PAI-1 is virtually unable to go latent and is stable at elevated temperature and pH for extended periods of time (t_½ = 145 h at 37°C, pH 7.4). Inhibits uPA (K_i = 5.1 x 10⁶ M^-1sec^-1) and tPA (K_i = 7.9 x 10⁵ M^-1sec^-1).

Highly purified preparation of an altered form of human PAI-1 containing four mutated amino acids. Mutant PAI-1 is virtually unable to go latent and is stable at elevated temperature and pH for extended periods of time (t_½ = 145 hours at 37°C, pH 7.4). Inhibits uPA (K_i = 5.1 x 10⁶ M^-1 sec^-1) and tPA (K_i = 7.9 x 10⁵ M^-1 sec^-1).

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Plasminogen Activator

Product does not compete with ATP.

Reversible: no

Target K_i: 5.1 x 106 M-1 sec-1, 7.9 x 105 M-1 sec-1 against uPA and tPA, respectively

Confezionamento

Please refer to vial label for lot-specific concentration.

Attenzione

Toxicity: Standard Handling (A)

Stato fisico

In 100 mM NaCl, 50 mM sodium phosphate buffer, 1 mM EDTA, pH 6.6.

Ricostituzione

Following initial thaw, aliquot and freeze (-70°C).

Altre note

Berkenpas, M.B., et al. 1995. EMBO J. 14, 2969.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable