79346

Forbolo 12-miristato 13-acetato

synthetic, ≥98.0% (TLC)

• Sinonimo/i: 12-O-tetradecanoilforbolo 13-acetato, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, PMA, TPA
• Formula empirica (notazione di Hill): C₃₆H₅₆O₈
• Numero CAS: 16561-29-8
• Peso molecolare: 616.83
• Beilstein: 2407201
• Numero MDL: MFCD00036736
• Codice UNSPSC: 12352211
• ID PubChem: 57652787
• NACRES: NA.25

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98.0% (TLC)
• Forma fisica: film
• Qualità: synthetic
• Solubilità: chloroform: 10 mg/mL, clear, colorless to light yellow
• Temperatura di conservazione: −20°C
• Stringa SMILE: CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(C)=O
• InChI: 1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1; PHEDXBVPIONUQT-RGYGYFBISA-N

Descrizione

Applicazioni

Phorbol 12-myristate 13-acetate has been used to stimulate the in vitro production of interleukin (IL)-18, IL-10 and macrophages. It has also been used to induce protein kinase C activity.

Azioni biochim/fisiol

Phorbol 12-myristate 13-acetate is a potent tumor promoter and activates protein kinase C in vivo and in vitro. It is a phorbol ester that is associated with many cellular responses including gene transcription, cell division and differentiation, apoptosis and immune response. It is also involved in protein kinase C (PKC) mediated receptor desensitization. Phorbol 12-myristate 13-acetate induces PKC localization from the cytosol, enabling the enzyme association with the cell membrane.

Altre note

Activates protein kinase C in vivo and in vitro at nanomolar concentrations; Highly potent tumor promotor and mitogen: active principle of croton oil. Review

Informazioni sulla sicurezza

• Pittogrammi: GHS05,GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H300 + H310 + H330 - H314 - H317 - H334 - H351
• Consigli di prudenza: P202 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
• Codice della classe di stoccaggio: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves