203732

Brevetoxin PbTx-2

from Ptychodiscus brevis, ≥95% (HPLC), solid, Na+ channel-binding neurotoxin, Calbiochem^®

• Sinonimo/i: Brevetoxin PbTx-2, Ptychodiscus brevis, Brevetoxin B, GbTx-2
• Formula empirica (notazione di Hill): C₅₀H₇₀O₁₄
• Numero CAS: 79580-28-2
• Peso molecolare: 895.08
• Codice UNSPSC: 51111800
• NACRES: NA.77

Proprietà

• product name: Brevetoxin PbTx-2, Ptychodiscus brevis, Lipid-soluble polyether neurotoxin that binds to Na⁺ channels on nerves and muscles causing an excessive influx of Na⁺ across membranes.
• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Colore: tan to white
• Solubilità: ethyl acetate: soluble; methanol: soluble; water: soluble
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• InChI: 1S/C50H70O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5,64-49)13-11-30-44(60-39)26(2)15-31-36(56-30)22-48(6)38(57-31)20-35-45(63-48)27(3)16-43(53)59-35/h9-10,16,24,26,28-42,44-45,52H,1,11-15,17-23H2,2-8H3/b10-9-; LYTCVQQGCSNFJU-KTKRTIGZSA-N

Descrizione

Descrizione generale

Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na⁺ channel activator that causes contractile paralysis in animal models. The excitatory action on nerve and muscle membranes is responsible for a wide spectrum of toxic effects, including massive transmitter release from nerve endings, muscle fasiculation, and ventricular fibrillation. The excitatory action is due to opening of the Na⁺ channels. The toxin does not bind either to the TTX or to the aconitine/veratridine sites.

Lipid-soluble polyether neurotoxin that binds to Na⁺ channels on nerves and muscles causing an excessive influx of Na⁺ across membranes. Binds at site 5 on the voltage-sensitive Na⁺ channel.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Neurotoxin that binds to Na+ channels on nerves and muscles.

Product does not compete with ATP.

Reversible: no

Confezionamento

Packaged under inert gas

yes

Attenzione

Toxicity: Highly Toxic (H)

Ricostituzione

Following reconstitution, aliquot, purge with iniert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.





From Catalog:

Solubitlity- removed acetone, EtOAc

Altre note

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Edwards, R.A., et al. 1992. Mol. Brain Res.14, 64.
Trainer, V.L. 1991. Mol. Pharmacol.40, 988.
Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol.103, 1126.
Trainer, V.L., et al. 1990. ACS Symposium Series418, 166.
Baden, G. 1989. FASEB J.3, 1807.
Baden, D.G., et al. 1988. Toxicon26, 97.
Poli, M.A., et al. 1986. Mol. Pharmacol.30, 129.
Shimizu, Y., et al. 1986. J. Am. Chem. Soc.108, 514.
Nakanishi, K. 1985. Toxicon23, 473.
Baden, D.G., et al. 1982. Toxicon19, 455.
Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol.19, 345.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H300 + H310 + H330
• Consigli di prudenza: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Classi di pericolo: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable