178281

p-APMSF, Hydrochloride

Alternative to DFP and PMSF.

• Sinonimo/i: p-APMSF, Hydrochloride, p-Amidinophenylmethylsulfonylfluoride, HCl
• Numero CAS: 74938-88-8
• Numero MDL: MFCD00078902
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥97% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated
• Colore: white
• Solubilità: water: 25 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C8H9FN2O2S.ClH/c9-14(12,13)5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5H2,(H3,10,11);1H; KHLLRHIUKOJXLL-UHFFFAOYSA-N

Descrizione

Descrizione generale

Alternative to DFP and PMSF. An irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentration. Acts on C1r, C1s, Factor Xa, and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF.

An alternative to DFP and PMSF. Specific irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentrations. Acts on C1r, C1s, Factor Xa and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF. Stability is pH dependent: t_½ = 20 min at pH 6.0; 6 min at pH 7.0; 1 millisecond at pH 8.0.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
trypsin-like serine proteases

Product does not compete with ATP.

Reversible: no

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Unstable in solution; reconstitute just prior to use.

Altre note

Cole, T.C., et al. 1989. Biochim. Biophys. Acta 990, 254.
Laura, R., et al. 1980. Biochemistry19, 4859.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable