1.37156

Pyridoxine hydrochloride

EMPROVE^® EXPERT, Ph. Eur., BP, JP, USP, FCC

• Sinonimo/i: Pyridoxine hydrochloride, Adermine hydrochloride, PN HCl, Pyridoxol hydrochloride, Vitamin B₆ hydrochloride
• Formula empirica (notazione di Hill): C₈H₁₁NO₃ · HCl
• Numero CAS: 58-56-0
• Peso molecolare: 205.64
• Beilstein: 3632435
• Numero MDL: MFCD00012807
• Codice UNSPSC: 41116107

Proprietà

• agenzia: BP; JP; Ph. Eur.; USP
• Livello qualitativo: 500
• Conformità normativa: FCC
• Nome Commerciale: EMPROVE^® EXPERT
• Punto di fusione: 214-215 °C (lit.)
• applicazioni: clinical nutrition; liquid formulation; parenterals; pharmaceutical; vitamins, nutraceuticals, and natural products
• Temperatura di conservazione: 15-25°C
• Stringa SMILE: Cl[H].Cc1ncc(CO)c(CO)c1O
• InChI: 1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H; ZUFQODAHGAHPFQ-UHFFFAOYSA-N

Descrizione

Descrizione generale

For protein-based therapeutics, such as monoclonal antibodies (mAbs) or plasma derived proteins, often highly concentrated protein formulations are required to meet intended dosing regimens. However, this usually comes with elevated viscosities and presents a challenge in the manufacturing process and final formulation. Our Viscosity Reduction Excipient Platform reduces the viscosity and helps overcome challenges associated with highly concentrated protein solutions.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation.
Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Applicazioni

The Viscosity Reduction Platform is based on the combination of two new excipients, one amino acid component with one anionic component, that together can better reduce protein viscosity beyond levels achieved with single excipients. Also, combining the two components enables a balance of viscosity reduction and protein stabilization. Pyridoxine hydrochloride Emprove® Expert is part of this new proprietary technology platform. Also, Pyridoxine hydrochloride (Vitamin B6) is used in clinical nutrition for treatment of vitamin B6 deficiency, anemia, mental retardation, Parkinson′s syndrome, gestational diabetes, tetanus and atherosclerosis.

Confezionamento

1.37156.0100 / 100g / PE bottle
1.37156.1000 / 1kg / PE bottle
1.37156.9012 / 12kg / PE bucket

Note legali

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS05
• Avvertenze: Danger
• Indicazioni di pericolo: H318
• Consigli di prudenza: P280 - P305 + P351 + P338
• Classi di pericolo: Eye Dam. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable