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Key Documents

09-817

Sigma-Aldrich

Anti-JMJD1C Antibody

from rabbit, purified by affinity chromatography

Sinonimo/i:

JMJD, jumonji domain containing 1C, TR-interacting protein 8, thyroid receptor interacting protein 8, probable JmjC domain-containing histone demethylation protein 2C, thyroid hormone receptor interactor 8, Thyroid receptor-interacting protein 8, Jumonji

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Purificato mediante

affinity chromatography

Reattività contro le specie

human

Reattività contro le specie (prevista in base all’omologia)

chimpanzee (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), orangutan (based on 100% sequence homology), rabbit (based on 100% sequence homology)

tecniche

immunocytochemistry: suitable
western blot: suitable

N° accesso NCBI

NP_116165

N° accesso UniProt

Q15652

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... JMJD1C(221037)

Descrizione generale

JMJD1C (jumonji domain-containing protein 1C) is also known as TRIP8 and mutations in this histone demethylase have been linked to certain forms of autism. JMJD1C is also thought to work in reactivating genes in embryonic stem cells, pancreatic islet and gastric cancer. JMJD1C has also been implicated as a gene expression regulator. JMJD1C with WHISTLE have recently been shown to also play a role in mouse testis development. JMJD1C has been identified as a nuclear-receptor coactivator and is a candidate gene for autism.

Immunogeno

KLH-conjugated linear peptide corresponding to human JMJD1C.

Applicazioni

Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected JMJD1C in HeLa cells.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Histone Modifying Proteins
Use Anti-JMJD1C Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect JMJD1C also known as jumonji domain containing 1C or TR-interacting protein 8.

Qualità

Evaluated by Western Blot in HeLa nuclear extract.

Western Blot Analysis: 1 µg/mL of this antibody detected JMJD1C on 10 µg of HeLa nuclear extract.

Descrizione del bersaglio

~284 kDa observed

Stato fisico

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

Control
HeLa nuclear extract

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Genetics in medicine : official journal of the American College of Medical Genetics, 18(4), 378-385 (2015-07-17)
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Human colorectal cancer stem cells (CSCs) are tumour initiating cells that can self-renew and are highly tumorigenic and chemoresistant. While genetic mutations associated with human colorectal cancer development are well-known, little is known about how and whether epigenetic factors specifically

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