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C-016

Supelco

(−)-Cotinine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formula empirica (notazione di Hill):
C10H12N2O
Numero CAS:
486-56-6
Peso molecolare:
176.22
Numero CE:
200-659-6
Numero MDL:
MFCD00077696
Codice UNSPSC:
41116107
ID PubChem:
329774764
NACRES:
NA.24

Grado

certified reference material

Livello qualitativo

300

Forma fisica

liquid

Caratteristiche

SNAP-N-SPIKE®, SNAP-N-SHOOT®

Confezionamento

ampule of 1 mL

Produttore/marchio commerciale

Cerilliant®

Concentrazione

1.0 mg/mL in methanol

tecniche

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

applicazioni

forensics and toxicology

Formato

single component solution

Temperatura di conservazione

−20°C

Stringa SMILE

CN1C(CCC1=O)c2cccnc2

InChI

1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1
UIKROCXWUNQSPJ-VIFPVBQESA-N

Categorie correlate

Descrizione generale

An analytical reference standard of the major urinary metabolite of nicotine. Not only is cotinine a biomarker for users of nicotine products including cigarettes, cigars, and snuff, but it′s also an alkaloid found in tobacco. Suitable uses for this analytical reference standard include as a starting material in calibrators and controls for GC/MS and LC/MS applications in nicotine testing methods or clinical and diagnostic testing of nicotine biomarkers.

Applicazioni


  • Biomarker Analysis in Medical Research: Examination of prolidase as a potential indicator of inflammation associated with cigarette smoking, where (-)-cotinine is a key biomarker, enhances understanding of chronic inflammation and its biochemical pathways in smokers (Yıldırım & Kulaksızoglu, 2024).

  • Comparative Toxicology Studies: Research evaluating blood biomarkers of inflammation in users of heated tobacco products compares these markers, including (-)-cotinine, with non-smoking individuals, offering insights into the inflammatory effects of new tobacco product usage on health (Świątkowska et al., 2024).

Note legali

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Avvertenze

Danger

Indicazioni di pericolo

H225,H301 + H311 + H331,H370

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organi bersaglio

Eyes

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

49.5 °F - closed cup

Punto d’infiammabilità (°C)

9.7 °C - closed cup

Certificati d'analisi (COA)

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R R Watts et al.
Environmental health perspectives, 84, 173-182 (1990-03-01)
A two-day technical workshop was convened November 10-11, 1986, to discuss analytical approaches for determining trace amounts of cotinine in human body fluids resulting from passive exposure to environmental tobacco smoke (ETS). The workshop, jointly sponsored by the U.S. Environmental
Brian K Kit et al.
Pediatrics, 131(3), 407-414 (2013-02-13)
To examine exposure to tobacco smoke products (TSPs), environmental tobacco smoke (ETS), and in-home smoke among youth with asthma in the United States. Nationally representative, cross-sectional data from 2250 youth aged 4 to 19 years with current asthma in the
Carmen Iñiguez et al.
American journal of epidemiology, 178(7), 1067-1075 (2013-09-07)
In utero tobacco exposure has been associated with fetal growth restriction, but uncertainty remains about critical windows of exposure and specific effects on body segments. In the present study, we aimed to examine the association of maternal smoking with fetal
V Haufroid et al.
International archives of occupational and environmental health, 71(3), 162-168 (1998-05-20)
A minireview is presented concerning the use of cotinine as a tobacco-smoke exposure index. First, general considerations about methods for the determination of urinary cotinine are presented. Besides pure analytical aspects, this minireview considers major problems encountered in the establishment
Kuan-Yen Tung et al.
Environmental research, 124, 7-12 (2013-04-30)
Environmental tobacco smoke (ETS) is a hazardous component of indoor air, and may increase the risk of respiratory diseases, atherosclerosis and otitis media in children. In this study, we explored the relationship between time inside the house, ETS exposure and
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