791300P
Avanti
18:0 PE-DTPA
Avanti Research™ - A Croda Brand 791300P, powder
Sinonimo/i:
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (ammonium salt)
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About This Item
Formula empirica (notazione di Hill):
C55H118N9O17P
Numero CAS:
Peso molecolare:
1208.55
Codice UNSPSC:
12352211
NACRES:
NA.25
Prodotti consigliati
Saggio
>99% (TLC)
Stato
powder
Confezionamento
pkg of 1 × 5 mg (791300P-5mg)
Produttore/marchio commerciale
Avanti Research™ - A Croda Brand 791300P
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Descrizione generale
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (18:0 PE-DTPA) comprises synthetic phospholipid derivative of ethanolamine.
This chelate is used for preparing MRI contrast agents.
Applicazioni
18:0 PE-DTPA (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (ammonium salt)) has been used to chelate liposome-based cationic adjuvant formulation (CAF01). It has also been used in the liposome preparation for imaging studies
Azioni biochim/fisiol
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (18:0 PE-DTPA) or PE-DTPA binding and interaction with the Toll-like receptor-2 regulates immune response . PE-DTPA acts as a lipopolysaccharide antagonist and elicits rescue functionality in sepsis by blocking nuclear factor κ -light-chain-enhancer of activated B cells based transcription.
Confezionamento
5 mL Amber Glass Screw Cap Vial (791300P-5mg)
Note legali
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Codice della classe di stoccaggio
11 - Combustible Solids
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Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA
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