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Key Documents

Altri documenti

699852P

Avanti

3D-PHAD™

Avanti Research™ - A Croda Brand

Sinonimo/i:

Monophosphoryl 3-Deacyl Lipid A (Synthetic) Pat No. 9,241,988

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About This Item

Formula empirica (notazione di Hill):
C82H158N3O20P
Numero CAS:
1699735-79-9
Peso molecolare:
1537.11
Codice UNSPSC:
12352211
NACRES:
NA.25

Saggio

>99% (HPLC)

Forma fisica

powder

Confezionamento

pkg of 1 × 1 mg (699852P-1mg)
pkg of 1 × 5 mg (699852P-5mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand

applicazioni

vaccine development

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO)[C@@H](OP([O-])(O)=O)[C@@H]1OC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](O)[C@@H]2NC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H]2O.[NH4+]

Descrizione generale

Vaccination is well-accepted as an effective method to prevent infections by mounting pathogen-specific immune responses prior to the infection. Usually, immunization with vaccine antigens alone is not able to induce robust or long-lasting immune responses — resulting in failure of protective immunity against infections. Thus, adjuvants are required to enhance cellular or humoral immune responses upon immunization. Because vaccine adjuvants using Lipid A have proven to be safe and effective in inducing Th-1 type immune responses to heterologous proteins in animal and human vaccines, Avanti developed Phosphorylated HexaAcyl Disaccharide (PHAD™), the first fully synthetic monophosphoryl Lipid A available for use as an adjuvant in human vaccines.

Applicazioni

3D-PHAD™ has been used:
  • as a synthetic adjuvant for respiratory syncytial virus (RSV) vaccine
  • as a synthetic adjuvant to prepare hepatitis B virus (HBV) and virus-like particles (VLP)-based human papillomavirus (HPV) vaccines
  • in liposome preparation for the generation of army liposome formulation (ALF) for human immunodeficiency (HIV) gp140 antigen immunization studies in mice.

Azioni biochim/fisiol

3-deacyl-phosphorylated hexa-acyl disaccharide (3D-PHAD™) is derived from monophosphoryl lipid A. It is amphiphilic and associates with the virosomal membranes.

Confezionamento

2 mL Amber Glass Crimp Cap Vial (699852P-1mg)
2 mL Amber Glass Crimp Cap Vial (699852P-5mg)

Altre note

For R&D use only. Not for drug, household, or other uses.

Note legali

3D-PHAD is a trademark of Avanti Polar Lipids, LLC
Avanti Research is a trademark of Avanti Polar Lipids, LLC
PHAD is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

Certificati d'analisi (COA)

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Development of a virosomal RSV vaccine containing 3D-PHAD Adjuvant: formulation, composition, and long-term stability
Lederhofer J
Pharmaceutical Research, 35(9), 172-172 (2018)
Monica L Martin et al.
Malaria journal, 18(1), 377-377 (2019-11-30)
Indian-origin rhesus (InR) are preferred for research, but strict export restrictions continue to limit their use. Chinese-origin rhesus (ChR), although easier to procure, are genetically distinct from InR and differ in their immune response to infectious agents, such as the
Immune response to antigen adsorbed to aluminum hydroxide particles: Effects of co-adsorption of ALF or ALFQ adjuvant to the aluminum-antigen complex
Beck Z, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 275, 1219-1219 (2018)
Immunogenicity of HPV and HBV vaccines: adjuvanticity of synthetic analogs of monophosphoryl lipid A combined with aluminum hydroxide
Taleghani N, et al.
Acta Pathologica, Microbiologica et Immunological Scandinavica, 127(3), 150-157 (2019)

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