QBD10554

MAL-dPEG^®₂₄-TFP ester

• Formula empirica (notazione di Hill): C₆₄H₁₀₈F₄N₂O₂₉
• Peso molecolare: 1445.53
• Numero MDL: MFCD28505512
• Codice UNSPSC: 12352108
• ID PubChem: 329823943
• NACRES: NA.22

Proprietà

• Saggio: >90%
• Stato: solid or viscous liquid
• Impiego in reazioni chimiche: reactivity: thiol reactive; reagent type: cross-linking reagent; reactivity: amine reactive
• Architettura del polimero: shape: linear; functionality: heterobifunctional
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C(OC1=C(C(F)=CC(F)=C1F)F)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O
• InChI: ROVWSNWDFQZUAW-UHFFFAOYSA-N

Descrizione

Caratteristiche e vantaggi

MAL-dPEG^®₂₄-TFP esters is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG^® spacer arm and an amine-reactive active ester on the other end. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. 2,3,5,6-tetrafluorophenyl (TFP) ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG^® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG^® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

Note legali

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable