936197

AdQPhos Pd G3

• Sinonimo/i: AdQPhos G3 Palladacycle, AdQPhos Palladacycle
• Formula empirica (notazione di Hill): C₇₃H₇₂FeNO₃PPdS
• Peso molecolare: 1236.66
• Codice UNSPSC: 12352142
• NACRES: NA.22

Proprietà

• Saggio: ≥90%
• Livello qualitativo: 100
• Forma fisica: powder
• Impiego in reazioni chimiche: reaction type: Cross Couplings
• Gruppo funzionale: (palladium); phosphine
• Stringa SMILE: CS(O[Pd]1([P](C23C[C@H]4C[C@H](C[C@H](C4)C3)C2)(C56C[C@H]7C[C@H](C[C@H](C7)C6)C5)c8cccc8)[NH2]C(C=CC=C9)=C9C%10=C1C=CC=C%10)(=O)=O.c%11(C%12=CC=CC=C%12)c(C%13=CC=CC=C%13)c(C%14=CC=CC=C%14)c(C%15=CC=CC=C%15)c%11C%16=CC=CC=C%16.[Fe]

Descrizione

Descrizione generale

The precatalysts derived from AdQPhos exhibit excellent activity towards palladium-catalyzed α-arylation reactions under milder conditions. The strength of these catalytic systems in enabling such reactions were demonstrated with the broad scope of nucleophiles, including nitroalkanes, nitriles, amides, esters, and ketones. Compared to other state-of-the-art catalysts, this system was far superior and served as the first versatile catalytic system to accommodate all these nucleophiles in this context.

Further, by merging with micellar catalysis, this catalytic system demonstrated the feasibility of enabling α-arylation reactions under mild aqueous conditions. This approach provides an environmentally benign alternative to toxic/hazardous solvents like 1,4-dioxane or NMP, bringing modern organic synthesis closer to being ideally sustainable.

Applicazioni

In addition to facilitating α-arylations, these catalysts demonstrate compatibility with various challenging cross-coupling reactions, such as Suzuki-Miyaura, Buchwald-Hartwig aminations, and C-O and C-S cross-couplings.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable