Passa al contenuto
Merck
Tutte le immagini(1)

Documenti fondamentali

Visualizza tutta la documentazione

933562

Sigma-Aldrich

NanoFabTx™ - Synthetic Folate Lipid Mix

for synthesis of folate functionalized liposomes for targeted delivery

Sinonimo/i:

Cholesterol, Drug delivery, Folate-PEG-DSPE, Hydro Soy PC, LNP, Microfluidics, NanoFab reagent kit, Nanoformulation, Nanoparticle, PE-PEG

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Codice UNSPSC:
12352211
NACRES:
NA.21

Livello qualitativo

100

Temperatura di conservazione

−20°C

Applicazioni

NanoFabTx™ Synthetic Folate Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of folate-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of therapeutic drug molecules for targeted drug delivery applications without the need for lengthy trial-and-error optimization.
The NanoFabTx™ Synthetic Folate Lipid mix includes a lyophilized lipid blend containing rationally selected lipids that has been optimized to synthesize folate-functionalized liposomes of a desired size range. The synthesized folate-functionalized liposomes enable selectively targeting cells which overexpressed folate-receptors (e.g., HeLa cells) and delivery both hydrophilic and hydrophobic drugs.

Caratteristiche e vantaggi

  • A ready-to-use nanoformulation lipid blend for the synthesis of folate-functionalized liposomes
  • Step-by-step extrusion and microfluidics protocols developed and tested by our formulation scientists
  • Flexible synthesis methods to create uniform and reproducible liposomes
  • Protocols and lipid blend optimized to synthesize liposomes around 100 nm with low polydispersity
  • Lipid mix optimized for folate-functionalized liposomes for small molecule encapsulation
Comprehensive protocols for liposome synthesis are included:

  • A lipid film hydration and extrusion protocol
  • A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Note legali

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
TMAX is a trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

Ci dispiace, ma al momento non ci sono COA disponibili online per questo prodotto.

Se ti serve aiuto, non esitare a contattarci Servizio Clienti

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Mahmoud M Omar et al.
International journal of nanomedicine, 16, 683-700 (2021-02-05)
To develop an externally triggered rapid-release targeted system for treating ovarian cancer, gemcitabine (GMC) was entrapped into sonosensitive (SoS) folate (Fo)-modified liposomes (LPs). GMC-loaded LPs (GMC LPs), GMC-loaded Fo-targeted LPs (GMC-Fo LPs), and GMC-loaded Fo-targeted SoS LPs (GMC-SoS Fo LPs)
Yan Tie et al.
Signal transduction and targeted therapy, 5(1), 6-6 (2020-04-17)
Tumor-associated macrophages (TAMs) facilitate cancer progression by promoting tumor invasion, angiogenesis, metastasis, inflammatory responses, and immunosuppression. Folate receptor β (FRβ) is overexpressed in TAMs. However, the clinical significance of FRβ-positive macrophages in lung cancer remains poorly understood. In this study

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.