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165344

Sigma-Aldrich

1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide methiodide

for peptide synthesis

Sinonimo/i:

EDC methiodide

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About This Item

Formula condensata:
C2H5N=C=N(CH2)3N(CH3)3I
Numero CAS:
22572-40-3
Peso molecolare:
297.18
Numero CE:
245-095-1
Numero MDL:
MFCD00011833
Codice UNSPSC:
12352116
ID PubChem:
24850134
NACRES:
NA.22

product name

1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide methiodide,

Forma fisica

powder

Livello qualitativo

200

Impiego in reazioni chimiche

reaction type: Coupling Reactions

Punto di fusione

97-99 °C (lit.)

applicazioni

peptide synthesis

Temperatura di conservazione

2-8°C

Stringa SMILE

[I-].CCN=C=NCCC[N+](C)(C)C

InChI

1S/C9H20N3.HI/c1-5-10-9-11-7-6-8-12(2,3)4;/h5-8H2,1-4H3;1H/q+1;/p-1
AGSKWMRPXWHSPF-UHFFFAOYSA-M

Categorie correlate

Applicazioni

  • Crosslinking agent

Reactant for:
  • Amide bond forming (amidation) crosslinking reactions
Water-soluble carboxyl modifying reagent for proteins.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302 + H312 + H332,H315,H319,H335

Classi di pericolo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
MKCM9869
MKCH6550
MKCG7199
MKCC5614
MKBX8249V

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Cyrille Garnier et al.
Biochemistry, 41(39), 11770-11778 (2002-09-25)
The 90 kDa heat-shock protein (Hsp90) is one of the major stress proteins whose overall structure remains unknown. In this study, we investigated the influence of divalent cations Mg(2+) and Ca(2+) on the hydrodynamic properties and quaternary structure of Hsp90.
E Schaffitzel et al.
Biological chemistry, 382(8), 1235-1243 (2001-10-11)
In Escherichia coli, the ribosome-associated Trigger Factor (TF) cooperates with the DnaK system in the folding of newly synthesized cytosolic polypeptides. Here we investigated the functional relationship of TF and DnaK by comparing various functional properties of both chaperones. First
G Csaba et al.
Cell biology international, 30(5), 412-415 (2006-03-21)
The amount and localization of three hormones (histamine, endorphin and triiodothyronine [T(3)]) was measured in male and female rat peritoneal cells (lymphocytes, mast cells, monocyte-macrophage-granulocyte group [mo-gran]) using flow cytometry as well as confocal microscopy after paraformaldehyde (PFA) or EDAC
Q Paula Lei et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 813(1-2), 103-112 (2004-11-24)
An LC-MS/MS method for determination of the break down product of N-ethyl-N'-(3-dimethylaminopropyl) carbodiimide (EDC) urea derivative, EDU, has been developed and validated for monitoring the residual coupling reagents. Results indicate that the method exhibits suitable specificity, sensitivity, precision, linearity and
Takahiro Kishimoto et al.
Biopolymers, 79(3), 163-172 (2005-08-12)
Pro-Hyp-Gly is a characteristic amino acid sequence found in fibrous collagens, and (Pro-Hyp-Gly)(10), which has been widely used as a collagen-model peptide, forms a stable triple-helical structure. Here, we synthesized polypeptides consisting of the Pro-Hyp-Gly sequence by direct poly-condensation of
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Articoli

Carbodiimide-mediated peptide coupling

Carbodiimide-mediated peptide coupling remains to the most frequently used technique.

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