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Sigma-Aldrich

Diethyl azodicarboxylate solution

purum, ~40% in toluene (H-NMR)

Sinonimo/i:

1,2-Ethoxycarbonyl diazene solution, DEAD, Diethoxycarbonyldiazene solution, Diethyl azodiformate solution, NSC 3474, NSC 679015, Unifoam AZ-AE 200

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About This Item

Formula condensata:
C2H5OCON=NCOOC2H5
Numero CAS:
Peso molecolare:
174.15
Beilstein:
908662
Numero MDL:
Codice UNSPSC:
12352108
ID PubChem:
NACRES:
NA.22

Grado

purum

Livello qualitativo

Forma fisica

solid

Concentrazione

~40% in toluene (H-NMR)

Indice di rifrazione

n20/D 1.47

Temperatura di conservazione

2-8°C

Stringa SMILE

CCOC(=O)\N=N/C(=O)OCC

InChI

1S/C6H10N2O4/c1-3-11-5(9)7-8-6(10)12-4-2/h3-4H2,1-2H3/b8-7+
FAMRKDQNMBBFBR-BQYQJAHWSA-N

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Applicazioni

Diethyl azodicarboxylate (DEAD) is a reagent used in the Mitsunobu reaction.
DEAD can also be used as a reagent in the:
  • Synthesis of esters, ethers, amines, and thioethers of alcohols.
  • Oxidation of alcohols to carbonyl derivatives using ZnBr2 as a catalyst via dehydrogenation reaction.
  • Conversion of alcohol to an azide key intermediate in the total synthesis of immunostimulant α-galactosylceramides.
  • Synthesis of aza-β-lactams from aryl(alkyl)ketenes.
  • Synthesis of 1H-1,2,4-triazole-1,4(5H)-dicarboxylate derivatives.
  • Diels-Alder type reactions.

Reactant for preparation of:
  • Immunostimulants α-Galactosylceramides
  • Cellotriose and cellotetraose analogues as transition state mimics for mechanistic studies of cellulases
  • Bisubstrate inhibitors with molecular recognition at the active site of catechol-O-methyltransferase
  • Derivatives of F200 and S383 with cannabinoid CB1 receptor binding activities
  • Aza-β-lactams via NHC-catalyzed [2 + 2] cycloaddition with ketenes

Reagent for:
  • Annulation of N-protected imines
  • α-thiocyanation of enolizable ketones with ammonium thiocyanate
  • Diels-Alder reactions

Altre note

Reagent used in the Mitsunobu reaction, reviews

Avvertenze

Danger

Classi di pericolo

Aquatic Chronic 3 - Asp. Tox. 1 - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3

Organi bersaglio

Central nervous system, Respiratory system

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

105.8 °F - closed cup

Punto d’infiammabilità (°C)

41 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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I clienti hanno visto anche

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D.L. Hughes
Organic preparations and procedures international, 28, 127-127 (1996)
DEAD-(cat) ZnBr2 an efficient system for the oxidation of alcohols to carbonyl compounds
Cao HT and Gree R
Tetrahedron Letters, 50(13), 1493-1494 (2009)
The Mitsunobu reaction in the 21st century
Fletcher, S
Organic Chemistry Frontiers : An International Journal of Organic Chemistry / Royal Society of Chemistry, 2(6), 739-752 (2015)
Phosphine-mediated annulation of N-protected imines with DEAD
Lian Z, et al.
Tetrahedron, 67(11), 2018-2024 (2011)
Enantioselective synthesis of aza-β-lactams via NHC-catalyzed [2+ 2] cycloaddition of ketenes with diazenedicarboxylates
Huang X-L, et al.
The Journal of Organic Chemistry, 74(19), 7585-7587 (2009)

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