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Merck

GRIN2B

glutamate receptor, ionotropic, N-methyl D-aspartate 2B

Sinonimi:
GluN2B, MRD6, NMDAR2B, NR2B, hNR3
Specie:
ID UniProtKB:
ID gene:
  • Human(2904) Summary: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
  • Mouse(14812) glutamate receptor, ionotropic, NMDA2B (epsilon 2)
  • Rat(24410) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • chicken(417965) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • dog(494009) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • domestic cat(101094356) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • Horse(100063746) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • cow(537804) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • domestic guinea pig(100731840) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • naked mole-rat(101723091) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • sheep(101118179) glutamate receptor, ionotropic, N-methyl D-aspartate 2B

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Small Molecule - Agonist

N° Catalogo
Descrizione
Specie
Reversin 205, ≥98% (HPLC), film,
Specie
mouse, rat, human
D-Cycloserine, synthetic,
Specie
human
Dextromethorphan hydrobromide monohydrate, ≥99% (TLC),
Specie
human
N-Methyl-D-aspartic acid, ≥98% (TLC), solid,
Specie
human, rat
(S)-AMPA, ≥97%,
Specie
mouse, human, rat

Small Molecule - Allosteric Modulator

N° Catalogo
Descrizione
Specie
Acamprosate calcium, ≥98% (HPLC), powder,
Specie
human
Acamprosate calcium, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 400.48 (C10H20CaN2O8S2),
Specie
human
Acamprosate calcium, British Pharmacopoeia (BP) Reference Standard,
Specie
human

Small Molecule - Antagonist

N° Catalogo
Descrizione
Specie
DL-2-Aminoadipic acid, ≥99%,
Specie
rat
2-Phenylquinoline, 99%,
Specie
rat
Ro 25-6981 hydrochloride hydrate, ≥98% (HPLC), powder,
Specie
human
Ro 8-4304, solid,
Specie
human
Spermine, ≥97%,
Specie
rat, human

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
PhosphoDetect Anti-NMDA NR2B (pTyr¹⁴⁷²) Rabbit pAb, liquid, Calbiochem®,
Reattività con
rat
Applicazione
Anti-GRIN2B antibody produced in rabbit, affinity isolated antibody,
Reattività con
horse, human, mouse, rabbit, rat
Applicazione
immunohistochemistry
western blot
Anti-NMDAR2B Antibody, clone 5C18 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
bovine, canine, feline, monkey, mouse, rat
Applicazione
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-GRIN2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
Anti-NMDAR2B antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
western blot

Small Molecule - Blocker

N° Catalogo
Descrizione
Specie
N-(3,3-Diphenylpropyl)glycinamide, >98% (HPLC), solid,
Specie
human
Agmatine sulfate salt, ≥97%, powder,
Specie
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Specie
human
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Specie
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Specie
human

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
Pentamidine isethionate salt, powder,
Specie
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Specie
human
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Specie
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Specie
human
Acido L-glutammico, ReagentPlus®, ≥99% (HPLC),
Specie
rat, human

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting human GRIN2B,
Specie
human
MISSION® esiRNA, targeting mouse Grin2b,
Specie
mouse