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Merck

1141002

USP

克霉唑

United States Pharmacopeia (USP) Reference Standard

别名:

1-[(2-氯苯基)二苯基甲基]-1-H咪唑, 1-(o-氯-α,α-二苯基苄基)咪唑, 1-(o-氯三苯)咪唑

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About This Item

经验公式(希尔记法):
C22H17ClN2
CAS号:
分子量:
344.84
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

clotrimazole

製造商/商標名

USP

應用

pharmaceutical (small molecule)

格式

neat

SMILES 字串

Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4

InChI

1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H

InChI 密鑰

VNFPBHJOKIVQEB-UHFFFAOYSA-N

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Clotrimazole USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Clotrimazole and Betamethasone Dipropionate Cream
  • Clotrimazole Cream
  • Clotrimazole Lotion
  • Clotrimazole Lozenges
  • Clotrimazole Topical Solution
  • Clotrimazole Vaginal Inserts

分析報告

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他說明

Sales restrictions may apply.

象形圖

Exclamation markEnvironment

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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Jenna Corcoran et al.
Aquatic toxicology (Amsterdam, Netherlands), 152, 57-65 (2014-04-15)
Clotrimazole (CTZ) is a persistent imidazole antifungal agent which is frequently detected in the aquatic environment and predicted to bio-concentrate in fish. Common carp (Cyprinus carpio) were exposed to mean measured concentrations of either 1.02 or 14.63μgl(-1) CTZ for 4
P R Sawyer et al.
Drugs, 9(6), 424-447 (1975-01-01)
Clotrimazole 2, a synthetic imidazole derivative, is primarily used locally in the treatment of vaginal and skin infections due to yeasts and dermatophytes. In vitro, it is most active against Candida spp., Trichophyton spp., Microsporum spp. and Malazzesia fuffur (Pityrosporon
S Nishanth Kumar et al.
Medical mycology, 52(5), 482-490 (2014-06-12)
Candidiasis infections are caused by yeasts from the genus Candida. The types of infection range from superficial to systemic. Treatment often requires antifungals such as the azoles; however, increased use of these drugs has led to the generation of yeasts
H L Greenberg et al.
Pediatric dermatology, 19(1), 78-81 (2002-02-28)
The use of antifungal/corticosteroid combinations as topical therapy for dermatophytoses has been criticized as being less effective, more expensive, and the cause of more adverse cutaneous reactions than antifungal monotherapy. The combination of clotrimazole and betamethasone diproprionate (Lotrisone) is a
Kathryn L Turner et al.
Cerebral cortex (New York, N.Y. : 1991), 24(9), 2388-2400 (2013-04-16)
From the subventricular zone (SVZ), neuronal precursor cells (NPCs), called neuroblasts, migrate through the rostral migratory stream (RMS) to become interneurons in the olfactory bulb (OB). Ion channels regulate neuronal migration during development, yet their role in migration through the

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