1107004

氯霉素，大包装

United States Pharmacopeia (USP) Reference Standard

• 别名: D-(−)-苏-2,2-二氯-N-[β-羟基-α-(羟甲基)-β-(4-硝基苯基)乙基]乙酰胺, D-(−)-苏-2-二氯乙酰胺基-1-(4-硝基苯基)-1,3-丙二醇, D-苏-2,2-二氯-N-β[-羟基-α-(羟甲基)-4-硝基苯乙基]乙酰胺, 氯霉素
• 线性分子式: Cl₂CHCONHCH(CH₂OH)CH(OH)C₆H₄NO₂
• CAS号: 56-75-7
• 分子量: 323.13
• Beilstein: 2225532
• MDL號碼: MFCD00078159
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329749306
• NACRES: NA.24

属性

• 等級: pharmaceutical primary standard
• API 家族: chloramphenicol
• 製造商／商標名: USP
• mp: 149-153 °C (lit.)
• 應用: pharmaceutical (small molecule)
• 格式: neat
• SMILES 字串: OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
• InChI: 1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
• InChI 密鑰: WIIZWVCIJKGZOK-RKDXNWHRSA-N

说明

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Ph

應用

Chloramphenicol USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Chloramphenicol
• Chloramphenicol Injection
• Chloramphenicol Capsules
• Chloramphenicol Tablets
• Chloramphenicol Sodium Succinate
• Chloramphenicol Ophthalmic Ointment
• Chloramphenicol Compounded Oral Suspension, Veterinary
• Chloramphenicol Sodium Succinate for Injection

生化／生理作用

作用机制：氯霉素通过与50S核糖体亚基结合并阻止氨酰基tRNA附着于核糖体来阻断肽基转移酶步骤，从而抑制细菌蛋白质的合成。 它还抑制线粒体和叶绿体蛋白的合成以及（p）ppGpp的核糖体形成，从而抑制rRNA的转录。

耐药性机制：使用氯霉素乙酰转移酶会使产物乙酰化并使其失活。

抗菌谱：这是一种针对革兰氏阳性和革兰氏阴性细菌的广谱抗生素，主要用于眼科和兽医目的。

分析報告

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他說明

Sales restrictions may apply.

安全信息

• 象形圖: GHS08,GHS05
• 訊號詞: Danger
• 危險聲明: H318,H351,H361fd
• 防範說明: P202 - P280 - P305 + P351 + P338 - P308 + P313 - P405 - P501
• 危險分類: Carc. 2 - Eye Dam. 1 - Repr. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3