PHL80431

二氢杨梅素

phyproof^® Reference Substance

• 别名: (2R,3R)-3,5,7-三羟基-2-（3,4,5-三羟基苯基）-2,3-二氢色-4-酮, 3,3′,4′,5,5′,7-六羟基黄烷酮, DHM, 蛇葡萄素
• 经验公式（希尔记法）: C₁₅H₁₂O₈
• CAS号: 27200-12-0
• 分子量: 320.25
• MDL號碼: MFCD00189451
• 分類程式碼代碼: 41116107
• NACRES: NA.24

属性

• 等級: primary reference standard
• 產品線: phyproof^® Reference Substance
• 化驗: ≥95.0% (HPLC)
• 形狀: solid
• 製造商／商標名: PhytoLab
• SMILES 字串: O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC(O)=C(C(O)=C3)O)[C@H]1O
• InChI: 1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
• InChI 密鑰: KJXSIXMJHKAJOD-LSDHHAIUSA-N

说明

一般說明

该物质是具有指定绝对纯度（考虑色谱纯度、水、残留溶剂、无机杂质）的一级参考物质。确切的值见证书。生产商：PhytoLab GmbH & Co. KG

應用

• Hovenia dulcis: a Chinese medicine that plays an essential role in alcohol-associated liver disease. This review discusses the role of Hovenia dulcis, from which dihydromyricetin is derived, in treating alcohol-associated liver conditions, highlighting its mechanisms and therapeutic potentials (He YX, Liu MN, Wang YY, et al. 2024).


• Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway. This study explores how dihydromyricetin influences liver health, particularly in hepatic steatosis and insulin resistance, offering insights into its mechanisms through autophagy pathways (Yang Y, Qiu W, Xiao J, et al. 2024).


• Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin. Research identifies dihydromyricetin′s potential anti-aging effects on human skin by modulating DNA methylation, which could contribute to its broader use in dermatological products (Falckenhayn C, Bienkowska A, Söhle J, et al. 2023).


• Dihydromyricetin reverses capecitabine-induced peripheral myelin dysfunction through modulation of oxidative stress. This article provides evidence of dihydromyricetin′s protective effects against peripheral myelin damage due to oxidative stress, relevant in the treatment of certain neuropathies (Fang J, Lou S, Zhou X, et al. 2024).


• The Molecular Mechanism Underlying the Therapeutic Effect of Dihydromyricetin on Type 2 Diabetes Mellitus Based on Network Pharmacology, Molecular Docking, and Transcriptomics. This comprehensive study details the molecular interactions and pathways through which dihydromyricetin could affect type 2 diabetes, providing a foundation for its application in metabolic disorder treatments (Wen X, Lv C, Zhou R, et al. 2024).

生化／生理作用

二氢杨梅素 (Ampelopsin) 是一种具有抗氧化和抗癌活性的黄烷醇，具有抗酒精中毒作用。 它的抗酒精作用似乎是由于它在苯并二氮杂卓位点作为 GABA-A受体的正调节剂的作用。

法律資訊

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable