15022AST

Astec^® CHIROBIOTIC^® V2 Chiral (5 μm) HPLC Columns

L × I.D. 10 cm × 4.6 mm, HPLC Column

• 别名: CHIROBIOTIC V2 Chiral Chromatography Column
• 分類程式碼代碼: 41115700
• eCl@ss: 32110501
• NACRES: SB.52

属性

• product name: Astec^® CHIROBIOTIC^® V2手性HPLC色谱柱, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
• 材料: stainless steel column
• agency: suitable for USP L88
• 描述: HPLC column
• 產品線: Astec^®
• 包裝: pkg of 1 ea
• 製造商／商標名: Astec^®
• 參數: 0-45 °C temperature; 241 bar pressure (3500 psi)
• 技術: HPLC: suitable; LC/MS: suitable
• 長度 × 內徑: 10 cm × 4.6 mm
• 基質: High-purity silica gel particle platform; fully porous particle
• 基質活性組: vancomycin phase
• 粒徑: 5 μm
• 孔徑: 200 Å
• 工作pH值範圍: 3.5-7.0
• 分離技術: chiral

说明

一般說明

中性分子、酰胺、酸、酯和胺对这些基于万古霉素的CSP显示出相当大的对映选择性。在CHIROBIOTIC^® V的极性离子模式下，分离出各种各样的仲胺和叔胺分子。CHIROBIOTIC^® V已经表现出蛋白质固定相的许多分离特性，但同时具有出色的稳定性和更高的样品容量。一些尚未报道在任何其他手性固定相上得到分离的手性分析物被分离出来。CHIROBIOTIC^® V和V2的区别在于键合化学性质与载体颗粒的孔径不同，这赋予它们不同的选择性和制备能力。

• 键合相：万古霉素
• 工作pH范围：3.5 - 7.0
• 粒径：5、10或16 μm
• 孔径：100Å（CHIROBIOTIC^® V）或200Å（CHIROBIOTIC^® V2）

CHIROBIOTIC FAQ
CHIROBIOTIC参考书目
Chiral产品文献

應用

• Chiral analysis of dextromethorphan and levomethorphan in human hair by liquid chromatography-tandem mass spectrometry: This study utilized the CHIROBIOTIC^® V2 column to achieve chiral separation of dextromethorphan and levomethorphan in human hair, highlighting the column′s application in forensic toxicology for precise enantiomeric analysis (Ji et al., 2022).


• Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma: This research demonstrates the application of CHIROBIOTIC^® V2 for pharmacokinetic studies in rats, establishing a method for enantioselective determination that can be crucial for drug development and therapeutic monitoring (Zhang et al., 2016).


• New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase: The use of CHIROBIOTIC^® V2 column in developing a new HPLC method for the separation of warfarin enantiomers underscores its utility in clinical analysis and therapeutic drug monitoring, showing its broad applicability in biomedical research (Malakova et al., 2009).

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法律資訊

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany

CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC