推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~130 kDa
物種活性
mouse
濃度
~1.0 mg/mL
技術
western blot: 2.5-5.0 μg/mL using whole extracts of HEK-293T cells expressing mouse ULK2
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... ULK2(9706)
mouse ... Ulk2(29869)
rat ... Ulk2(303206)
一般說明
Uncoordinated family member (unc)-51 like autophagy activating kinase 2 (ULK2) is encoded by the gene mapped to mouse chromosome 11. Mouse ULK2 (mULK2) belongs to the UNC-51-like protein kinase family. mULK2 protein is characterized with an amino-terminal kinase domain, a central proline/serine rich (PS) domain and a carboxy-terminal (C) domain. ULK2 is ubiquitously expressed and is mainly localized to autophagosomal membranes in mammalian cells.
應用
Anti-ULK2 antibody produced in rabbit has been used in western blot analysis and immunohistochemistry.
生化／生理作用
Uncoordinated family member (unc)-51 like autophagy activating kinase 2 (ULK2) plays a crucial role in autophagy. It is also implicated in the regulation of elemental biological processes conserved among wide variety of species. Downregulated expression of the gene increases astrocyte transformation and tumor growth.
外觀
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
Nazio F
Nature Cell Biology, 15, 406-416 (2013)
Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse
Bi W
Genome Research, 12, 713-728 (2002)
Methylation Silencing of ULK2, an Autophagy Gene, Is Essential for Astrocyte Transformation and Tumor Growth
Shukla S
The Journal of Biological Chemistry, 289, 22306-22318 (2014)
Ammonia-induced autophagy is independent of ULK1/ULK2 kinases.
Cheong H
Proceedings of the National Academy of Sciences of the USA, 108, 11121-11126 (2011)
The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy
Lee EJ and Tournier C
Autophagy, 7, 689-695 (2011)
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