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Merck

T8325

Sigma-Aldrich

TDZD-8

≥98% (HPLC), needles

别名:

4-苄基-2-甲基-1,2,4-噻二唑烷-3,5-二酮

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About This Item

经验公式(希尔记法):
C10H10N2O2S
分子量:
222.26
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

needles

儲存條件

protect from light

顏色

white

mp

63-64.4 °C

溶解度

DMSO: >10 mg/mL

儲存溫度

2-8°C

SMILES 字串

CN1SC(=O)N(Cc2ccccc2)C1=O

InChI

1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

InChI 密鑰

JDSJDASOXWCHPN-UHFFFAOYSA-N

應用

TDZD-8已被用于研究GSK-3在维持MLL白血病干细胞转录过程中的作用。TDZD-8也被用于分析其对小鼠嗅球神经功能的影响

生化/生理作用

TDZD-8是GSK-3的一种选择性抑制剂、一种酰二唑烷酮衍生物、GSK-3β的一种非ATP竞争性抑制剂(IC50 = 2 μM)。它在>100 μM时不会抑制Cdk-1/cyclin B、CK-II、PKA或PKC。TDZD-8已被提出会与GSK-3β的激酶位点结合。

特點和優勢

《受体分类和信号转导》手册的 GSK-3 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

準備報告

TDZD-8以大于10 mg/ml的浓度溶于DMSO。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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