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Merck

T7375

Sigma-Aldrich

硫代烟酰胺腺嘌呤二核苷酸

≥90%

别名:

硫代烟酰胺-DPN

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About This Item

线性分子式:
C21H27N7O13SP2
CAS号:
分子量:
679.49
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

品質等級

化驗

≥90%

儲存溫度

−20°C

SMILES 字串

NC(=S)C1=CC=C[N](=C1)C2OC(COP(O)(=O)OP(O)(=O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O

InChI

1S/C21H28N7O13P2S/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(40-21)6-38-43(35,36)41-42(33,34)37-5-10-13(29)15(31)20(39-10)27-3-1-2-9(4-27)18(23)44/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H2,23,44)(H,33,34)(H,35,36)(H2,22,24,25)

InChI 密鑰

JFOSDPGFZXVRDA-UHFFFAOYSA-N

應用

硫代烟酰胺腺嘌呤二核苷酸在 S -腺苷-l-同型半胱氨酸 (AdoHcy) 水解酶 (SAHH) 抑制试验 和 NAD + 糖水解酶活性中被用作底物类似物。

生化/生理作用

硫代烟酰胺腺嘌呤二核苷酸 (sNAD) 是辅酶烟酰胺腺嘌呤二核苷酸 (NAD) 和 NADH 的类似物。NAD+ 激酶调节 NAD+水平,促进癌细胞的细胞毒性。

聯結

NAD 类似物

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Shigeru Ueda et al.
Analytical biochemistry, 332(1), 84-89 (2004-08-11)
We have established a simple kinetic model applicable to the enzyme cycling reaction for the determination of 3alpha-hydroxysteroids. This reaction was conducted under the reversible catalytic function of a single 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) with nucleotide cofactors, thio-NAD(+) (one of the
A Argyrou et al.
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Clinical and experimental medicine, 1(4), 201-209 (2002-03-29)
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NAD+ kinase as a therapeutic target in cancer
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