推荐产品
产品名称
Nα-甲苯磺酰基- L -赖氨酸氯甲基酮 盐酸盐, ≥96% (TLC), powder
生物源
synthetic (organic)
品質等級
化驗
≥96% (TLC)
形狀
powder
效力
10-100 μM effective concentration
溶解度
H2O: 50 mg/mL
儲存溫度
−20°C
SMILES 字串
Cl[H].Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl
InChI
1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1
InChI 密鑰
YFCUZWYIPBUQBD-ZOWNYOTGSA-N
基因資訊
human ... NFKB1(4790) , NFKB2(4791)
正在寻找类似产品? 访问 产品对比指南
應用
Nα-对甲苯磺酰-L-赖氨酸氯甲基酮盐酸盐已用于：
- 在胰凝乳蛋白酶纯化中抑制粗提液中的胰蛋白酶，从而防止其与亲和载体结合
- 作为组织和细胞匀浆的蛋白酶抑制剂
- 作为胰蛋白酶抑制剂测定特定蛋白酶的活性水平
生化／生理作用
Nα-对甲苯磺酰-L-赖氨酸氯甲基酮盐酸盐(TLCK)抑制脂多糖(LPS)或细胞因子诱导的核因子κB (NF-κB)活化，从而抑制诱导型一氧化氮合酶(iNOS)和环氧合酶(COX-2)的转录激活。它可抑制所有有丝分裂原诱导的pp70s6k激活。还可通过抑制某些细胞株中和刺激下发生的胱天蛋白酶过程而抑制细胞株凋亡。
包裝
无底玻璃瓶。内含物在插入的融合锥内。
注意
20°C 干燥条件下储存时至少可稳定两年。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
P Kwo et al.
The American journal of physiology, 268(4 Pt 1), G613-G621 (1995-04-01)
Glycodeoxycholate (GDC) induces apoptosis in hepatocytes by a mechanism associated with DNA cleavage by endonucleases. In many models of apoptosis, proteolysis is required prior to DNA cleavage. Our aims were to determine if enhanced proteolysis is a mechanism causing GDC-mediated
Purification and characterization of a serine protease with fibrinolytic activity from the dung beetles, Catharsius molossus
Ahn MY, et al.
Thrombosis Research, 112(5-6), 339-347 (2003)
G Kwon et al.
Diabetes, 47(4), 583-591 (1998-05-06)
Interleukin-1beta (IL-1beta) has been implicated as an effector molecule of beta-cell destruction in autoimmune diabetes. IL-1beta inhibits insulin secretion from pancreatic beta-cells by stimulating the expression of inducible nitric oxide synthase (iNOS) that generates the free radical nitric oxide. IL-1beta
Swaantje Peters et al.
Cytokine, 40(2), 144-150 (2007-10-26)
Vascular permeability is important at many sites, but particularly so in diabetic retinopathy where macular oedema is the major cause of blindness. Angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) are important factors involved in neovascularization and vascular leakage, but
L Stefanis et al.
Journal of neurochemistry, 69(4), 1425-1437 (1997-11-05)
Rat pheochromocytoma (PC12) cells and sympathetic neurons undergo apoptotic cell death upon withdrawal of trophic support. We have shown previously that selective cysteine aspartase (caspase) inhibitors protect PC12 cells and sympathetic neurons from such death, and that the caspase Nedd-2
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门