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一般說明
脱铁转铁蛋白(aTF)可以补充铁或用于结合培养基中存在的游离铁,它还可用于将铁运输到哺乳动物细胞中。
應用
脱铁转铁蛋白已作为补充剂:
- 用于杜氏改良Eagle培养基/HamF12(DMEM/F-12),以培养人肾上腺皮质癌细胞
- 在DMEM/F-12中培养小鼠神经前体细胞
- 收集NCSU23培养基培养猪卵巢腔前卵泡
生化/生理作用
脱铁转铁蛋白(aTF)是一种内源性铁螯合剂,通过清除游离铁和防止有毒活性氧(ROS)的形成对宿主起到保护作用。它对地中海贫血有治疗作用。铁释放后,受体结合的脱铁转铁蛋白到达细胞表面,而不是被运输到溶酶体降解。细胞表面具有中性的pH值,促进脱铁转铁蛋白从受体释放,在此处再次循环并结合额外的铁,以进一步将铁传递到细胞。
其他說明
非血红素铁转运蛋白。
免責聲明
供研究使用在法国,在用于科研目的时(包括进口和出口活动(《公共健康法》第L 1211-1条,第2节))该产品为管制品。购买者(即最终用户)需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
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