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一般說明
转铁蛋白主要在肝脏中合成，是血清中含量丰富的糖蛋白。转铁蛋白超家族成员具有相似的多肽折叠模式。转铁蛋白含有N端和C端铁结合同源结构域。这些结构域中的每一个都被分裂成两个子结构域，在子结构域间隙内具有铁和阴离子的结合位点。绑定间隙随着铁释放和铁绑定打开和关闭。脱铁转铁蛋白是一种无铁蛋白，在转铁蛋白与其受体分离后产生。此产物可以补充铁或用于结合培养基中存在的游离铁。
應用
脱铁转铁蛋白已用于：
- 培养人原代胰腺内皮细胞、Het1As（非肿瘤食管细胞）和永生化人结肠上皮细胞（HCEC-1CT）
- 培养α小鼠肝12（AML-12）（成熟肝细胞）细胞
- 作为晶体学前纯化的人脱铁转铁蛋白的来源
生化／生理作用
转铁蛋白负责将铁从吸收和储存的部位运送到组织细胞。它能维持生物体液中的铁含量。转铁蛋白的水平可以反映总铁结合能力（TIBC）。转铁蛋白为骨髓中红细胞的血红蛋白提供所需的铁元素。缺铁会导致转铁蛋白水平升高。怀孕和服用雌激素也会提高转铁蛋白的水平。慢性肝病、肾功能不全、营养不良和蛋白质丢失性肠病会减少转铁蛋白的合成。
其他說明
非血红素铁转运蛋白。
免責聲明
供研究使用在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
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