所有图片(1)
About This Item
经验公式（希尔记法）:
C16H8N2O2Cl4
CAS号:
分子量:
402.06
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
white
溶解度
DMSO: >10 mg/mL
H2O: insoluble
儲存溫度
2-8°C
SMILES 字串
Clc1cnc(Oc2ccc(Oc3ncc(Cl)cc3Cl)cc2)c(Cl)c1
InChI
1S/C16H8Cl4N2O2/c17-9-5-13(19)15(21-7-9)23-11-1-2-12(4-3-11)24-16-14(20)6-10(18)8-22-16/h1-8H
InChI 密鑰
BAFKRPOFIYPKBQ-UHFFFAOYSA-N
基因資訊
human ... NR1I3(9970)
應用
TCPOBOP 已被用于增强小鼠肝癌细胞中 Mcl-1-斜体启动子的功能。TCPOBOP 也被用于研究组成型雄烷受体 (CAR) 诱导小鼠肝细胞基因表达。
生化／生理作用
TCPOBOP 作为 CAR 的剂量依赖性直接激动剂，可增强细胞色素 P450 (CYP) 的核受体 CAR 转活。是苯巴比妥类 CYP 诱导剂中已知最有效的成分。
特點和優勢
该化合物是细胞凋亡研究的特色产品。点击此处，发现更多特色细胞凋亡产品。如需了解有关生物活性小分子在其他研究领域的更多信息，请访问sigma.com/ discover-bsm。
準備報告
TCPOBOP 可溶于 DMSO，浓度大于 10 mg/mL。不溶于水。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Albert Braeuning et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(5), 1138-1145 (2009-02-25)
Basal as well as xenobiotic-induced expression of the main enzymes from phase I and phase II of drug metabolism is confined to the perivenous areas of the mammalian liver lobule. Whereas signal transduction pathways that govern xenobiotic-induced expression of these
Christopher Reed et al.
The American journal of pathology, 184(6), 1853-1859 (2014-04-15)
Diverse etiologic events are associated with the development of hepatocellular carcinoma. During hepatocarcinogenesis, genetic events likely occur that subsequently cooperate with long-term exposures to further drive the progression of hepatocellular carcinoma. In this study, the frequent loss of the retinoblastoma
Nicholas J Lodato et al.
Toxicological sciences : an official journal of the Society of Toxicology, 164(1), 115-128 (2018-04-05)
Activation of the nuclear receptor and transcription factor CAR (Nr1i3) by its specific agonist ligand TCPOBOP (1, 4-bis[2-(3, 5-dichloropyridyloxy)]benzene) dysregulates hundreds of genes in mouse liver and is linked to male-biased hepatocarcinogenesis. To elucidate the genomic organization of CAR-induced gene
Josiah E Hardesty et al.
Xenobiotica; the fate of foreign compounds in biological systems, 47(9), 807-820 (2016-07-28)
1. Polychlorinated biphenyls (PCBs) are persistent environmental pollutants that disrupt hepatic xenobiotic and intermediary metabolism, leading to metabolic syndrome and nonalcoholic steatohepatitis (NASH). 2. Since phenobarbital indirectly activates Constitutive Androstane Receptor (CAR) by antagonizing growth factor binding to the epidermal growth factor
Savvina Moustafa et al.
Journal of virology, 92(9) (2018-02-16)
Viruses often encompass overlapping reading frames and unconventional translation mechanisms in order to maximize the output from a minimum genome and to orchestrate their timely gene expression. Hepatitis C virus (HCV) possesses such an unconventional open reading frame (ORF) within
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