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生物源
bovine thyroid
品質等級
化驗
≥90% (agarose gel electrophoresis)
形狀
powder
分子量
~670 kDa
成份
Iodine, ≥0.20%
氮分析
13.0-16.0% total
灰分
≤4%
溶解度
H2O: 20 mg/mL
UniProt登錄號
儲存溫度
−20°C
基因資訊
cow ... TG(280706)
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應用
牛甲状腺球蛋白可刺激大鼠甲状腺滤泡细胞以及原代猪甲状腺上皮细胞的增殖。这种效应是通过 PI3K 信号传导介导的。
通常用作生产抗体的载体蛋白。其优点在于大量的酪氨酸残基可用于重氮反应进行偶联。
生化／生理作用
储存在甲状腺中的含碘蛋白质。当甲状腺受到来自垂体的促甲状腺激素（TSH） 的刺激时，转化为循环甲状腺素。因为其表达是甲状腺所独有的，它是甲状腺消融治疗后甲状腺癌复发或转移的敏感指标。
牛甲状腺球蛋白是一种大的四聚体糖蛋白，由甲状腺产生，是甲状腺激素的前体。其尺寸大且在正常条件下不存在于血浆中，这使其具有很强的免疫原性，并降低了在免疫测定中这种载体蛋白的抗体与血浆蛋白发生交叉反应的机会。半抗原可以通过附近的仲胺与甲状腺球蛋白偶联。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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With the emergence of mass spectrometry for the clinical measurement of proteins in biological matrices, the development of biological reference materials will continue to grow in importance.
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