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一般說明
Human albumin is encoded by ALB gene that is mapped to human chromosome 4q. The gene is developmentally regulated and is synthesized by the liver. The encoded protein has a molar mass of 65,000 Da and consists of a single polypeptide chain of 585 amino acids.
應用
Albumin has been used in ion exchange chromatography to compare the albumin isolated from whole human plasma. It has been used to bind to phage clones in phage binding assay.
生化／生理作用
Human albumin is a globular unglycosylated serum protein that makes up for more than half of the total plasma or serum proteins. It functions in the maintenance of COP (cellular oncotic pressure). It binds to hydrophobic organic anions such as, bilirubin, long-chain fatty acids and haematin and some cations such as magnesium and calcium. It also serves as a secondary or tertiary carrier for steroids, vitamin D and thyroxine. It is involved in the catabolism of prostaglandins and metabolism of certain endogenous substances, such as lipids, and eicosanoids. It acts as a plasma buffer and scavenges oxygen free radicals, thus reducing the pathological effects of certain inflammatory diseases. Mutation in the gene coding for albumin leads to familial dysalbuminaemic hyperthyroidism.
外觀
Lyophilized as a salt free solid.
訊號詞
Danger
危險聲明
危險分類
Resp. Sens. 1A
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4.
Minghetti PP
The Journal of Biological Chemistry, 261, 6747-6757 (1986)
Isolation of albumin from whole human plasma and fractionation of albumin-depleted plasma.
Travis J
The Biochemical Journal, 157, 301-306 (1976)
The role of albumin in critical illness.
Nicholson JP
British Journal of Anaesthesia, 85, 599-610 (2000)
Albumin binding as a general strategy for improving the pharmacokinetics of proteins.
Dennis MS
The Journal of Biological Chemistry, 277, 35035-35043 (2002)
Chelsea Miller et al.
Journal of biomedical materials research. Part A, 111(8), 1096-1109 (2023-01-03)
Surface modifications can be applied to biomaterials to alter the various surface properties that influence protein-material interactions and the cellular response. The plasma protein fetuin-A has been found to adsorb to many biomaterials but details of its interactions with polydimethylsiloxane
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