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一般說明
Apolipoprotein E (ApoE) belongs to a group of proteins that bind reversibly with lipoproteins. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers have significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. The gene encoding this protein is localized on human chromosome 19q13.32. Recombinant human ApoE2 is a 34.3kDa protein containing 300 amino acid residues.
生化／生理作用
In addition to facilitating solubilization of lipids, apolipoproteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Apolipoprotein E (ApoE) plays an important role in lipid metabolism. It′s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (Apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III.
外觀
Sterile filtered and Lyophilized without additives.
準備報告
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
重構
Reconstitute in dH2O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.
免責聲明
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
从最新的版本中选择一种：
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Deelen J
Aging Cell, 10(4), 686-698 (2011)
Apolipoprotein E isoforms and lipoprotein metabolism.
Phillips MC
IUBMB Life, 66(9), 616-623 (2014)
Apolipoprotein E-low density lipoprotein receptor binding: study of protein-protein interaction in rationally selected docked complexes.
Prevost M and Raussens V
Proteins: Structure, Function, and Genetics, 55(4), 874-884 (2004)
Molecular mechanism of apolipoprotein E binding to lipoprotein particles.
Nguyen D
Biochemistry, 48(13), 3025-3032 (2009)
Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes.
Mahley RW
Journal of Lipid Research, 40(11), 1933-1949 (1999)
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