推荐产品
生物源
human
重組細胞
expressed in E. coli
化驗
≥90% (SDS-PAGE)
形狀
lyophilized
分子量
15-16 kDa
包裝
pkg of 10 μg
儲存條件
avoid repeated freeze/thaw cycles
雜質
endotoxin, tested
NCBI登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... VEGFC(7424)
一般說明
The recombinant VEGF-C (vascular endothelial growth factor-C) is a 125 amino acid protein that lacks the N-terminal signal peptide (from T103 to R227 of Gene Bank U58111). Human VEGF-C exhibits about 85% homology with mouse VEGF-C. The VEGFC gene is mapped to human chromosome 4q34.3.
應用
VEGF-C human has been used to determine cell proliferation and survival.
生化／生理作用
VEGF-C (vascular endothelial growth factor-C) promotes tumorigenesis, by inducing lymphatic metastasis. The production of VEGF-C is stimulated by pro-fibrotic transforming growth factor β. The main function of VEGF-C is to mediate lymphangiogenesis. Overexpression of VEGF-C in keratinocytes of skin causes dermal lymphatic vessel hyperplasia.
外觀
Lyophilized without additives.
重構
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis
Kinashi H, et al.
Kidney International, 92(4), 850-863 (2017)
The effect of vascular endothelial growth factor in the progression of bladder cancer and diabetic retinopathy
Aldebasi YH, et al.
International Journal of Clinical and Experimental Medicine, 6(4), 239-239 (2013)
Tumor necrosis factor superfamily 15 promotes lymphatic metastasis via upregulation of vascular endothelial growth factor-C in a mouse model of lung cancer
Qin T, et al.
Cancer Science, 109(8), 2469-2469 (2018)
Angiogenesis: From Basic Science to Clinical Applications, 58-58 (2006)
Kazuhide Hayakawa et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(29), 10666-10670 (2011-07-22)
Originally identified as an angiogenic factor, vascular endothelial growth factor (VEGF-A) is now known to play multiple roles in the CNS, including the direct regulation of neuronal and astrocytic functions. Here, we ask whether VEGF-A can also have a novel
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