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Key Documents

SRP3330

Sigma-Aldrich

IL-6 来源于小鼠

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

别名:

BSF-2, HPGF, IFN-?2, B 细胞分化因子(BCDF)

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About This Item

分類程式碼代碼:
12352202
NACRES:
NA.32

生物源

mouse

重組細胞

expressed in E. coli

化驗

≥98% (HPLC)
≥98% (SDS-PAGE)

形狀

lyophilized

效力

5x10^7 units/mg ED50

分子量

21.7 kDa

包裝

pkg of 10 μg

雜質

endotoxin, tested

顏色

white to off-white

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

mouse ... IL6(16193)

一般說明

鼠IL-6对人细胞无活性,而人和鼠IL-6对鼠细胞的活性相同。 重组鼠IL-6是含有188个氨基酸残基的21.7 kDa蛋白质。

應用

来自小鼠的IL-6已用于研究IL-6介导的对小鼠前脂肪细胞分化的抑制作用。

生化/生理作用

IL-6是一种多效细胞因子,它能够调节免疫和炎症反应,从而在宿主防御中发挥重要作用。IL-6由T细胞、单核细胞、成纤维细胞、内皮细胞和角质形成细胞产生,具有多种生物学功能。它能刺激B细胞分化和抗体产生,与IL-3协同作用于巨核细胞发育和血小板生成,诱导肝急性期蛋白的表达,并调节骨代谢。IL-6通过IL-6受体系统发出信号,该系统由IL-6R和gp130两条链组成。

外觀

从0.1%TFA中冻干获得

重構

打开样品瓶之前需离心。 在水中重悬至浓度为 0.1-1.0mg/ml。不可涡旋。 该溶液可在2-8°C下储存长达1周。 为了延长储存时间,建议可在含有载体蛋白(如0.1% BSA)的缓冲液中进行进一步的稀释,并分装冻存在-20℃至-80℃下。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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The biology of interleukin-6.
Kishimoto T
Blood, 74, 1-10 (1989)
Polyinosinic-polycytidylic acid inhibits the differentiation of mouse preadipocytes through pattern recognition receptor-mediated secretion of tumor necrosis factor-a.
Yu L
Immunology and Cell Biology, 94, 875-885 (2016)
T Kishimoto et al.
Science (New York, N.Y.), 258(5082), 593-597 (1992-10-23)
Many cytokines and cytokine receptors involved in the regulation of hematopoiesis, immune responses, and inflammation have been identified and characterized at the molecular level. Several characteristic features of cytokines, such as pleiotropy and redundancy, are now more clearly understood on
Georgios Koulaxouzidis et al.
Journal of reconstructive microsurgery, 31(7), 508-515 (2015-06-27)
Systemic alteration of interleukin-6 (IL-6) influences peripheral nerve regeneration. We investigated the potential influences of in situ (at the coaptation site) IL-6 modulation in a peripheral-nerve-transection/sciatic-nerve-graft in vivo model. We quantified the elongation of regenerating axons, the number of arborizing
Lili Yu et al.
Immunology and cell biology, 94(9), 875-885 (2016-10-19)
Viral infections can disturb the functions of adipose tissues and thus result in metabolic diseases. Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors

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