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Key Documents

SRP3089

Sigma-Aldrich

IL-22 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

别名:

IL-TIF

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About This Item

分類程式碼代碼:
12352202
NACRES:
NA.32

生物源

human

重組細胞

expressed in E. coli

化驗

≥98% (HPLC)
≥98% (SDS-PAGE)

形狀

lyophilized

分子量

32.8 kDa

包裝

pkg of 10 μg

技術

cell culture | mammalian: suitable

雜質

<0.1 EU/μg endotoxin, tested

顏色

white to off-white

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

human ... IL22(50616)

一般說明

IL22 (interleukin 22) is a member of the IL10 related cytokine family, and this gene is localized to the human chromosome 12q15. This protein is predominantly produced by activated CD4+ T cells, and its target cells include mesangial, neuronal and hepatoma cell types. Recombinant human IL-22 is a 33.6 kDa non-disulfide-linked homodimeric protein containing of two 147 amino acid polypeptide chains.

生化/生理作用

IL22 (interleukin 22) is responsible for eliciting acute-phase responses including, anemia, weight loss, increase in platelet numbers, elevated serum amyloid A and fibrinogen levels and reduced levels serum albumin levels. During inflammation, this protein leads to an increase in pancreatitis-associated protein 1 (PAP1) and osteopontin in pancreatic acinar cells, which might either have protective or trophic effects. This protein is involved in the crosstalk between keratinocytes and inflammatory cells. It is linked with tumorigenesis and progression of tumors. 429 C/T polymorphism in this gene is linked with susceptibility to bladder cancer. In patients with recurrent pregnancy loss, the expression of IL22 is reduced in the uterine decidua, which might lead to disruption of decidual homeostasis, and hence, early loss of pregnancy.

序列

MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI

外觀

Lyophilized from 10 mM NaCitrate, pH 3.0

重構

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Expression of interleukin-22 in decidua of patients with early pregnancy and unexplained recurrent pregnancy loss.
O'Hern Perfetto C, et al.
Journal of Assisted Reproduction and Genetics, 32(6), 977-984 (2015)
Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26.
Oral HB, et al.
European Journal of Immunology, 36(2), 380-388 (2006)
Tao Zhao et al.
Clinics (Sao Paulo, Brazil), 70(10), 686-690 (2015-11-26)
The cytokine interleukin-22 (IL-22), which is produced by T cells and natural killer cells, is associated with tumorigenesis and tumor progression in cancers. However, the role of IL-22 in bladder cancer has not been investigated. A prospective hospital-based case-control study
Sergei V Kotenko
Cytokine & growth factor reviews, 13(3), 223-240 (2002-12-19)
Five novel cytokines (IL-19, IL-20, IL-22 (IL-TIF), IL-24 (human MDA-7, mouse FISP, rat C49A/Mob-5), and IL-26 (AK155)) demonstrating limited primary sequence identity and probable structural homology to IL-10 have been identified. These cellular cytokines, as well as several cytokines encoded
María J Loera-Arias et al.
Biotechnology letters, 36(12), 2489-2494 (2014-09-13)
Interleukin-22 (IL-22) participates in the modulation of innate immunity and inflammation. This cytokine has important therapeutic potential, such as with ulcerative colitis, liver and lung injury, and infection, in different animal models. We generated a Lactococcus lactis strain that secretes

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