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生物源
human
重組細胞
expressed in E. coli
化驗
≥98% (HPLC)
≥98% (SDS-PAGE)
形狀
lyophilized
效力
20-40 ng/mL
分子量
17.2 kDa
包裝
pkg of 100 μg
技術
cell culture | mammalian: suitable
雜質
<0.1 EU/μg endotoxin, tested
顏色
white to off-white
適合性
suitable for molecular biology
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... IL1R1(3554)
一般說明
基因IL-1RA（白细胞介素-1受体拮抗剂）定位于人染色体2q上。 它属于IL-1（白细胞介素1）蛋白家族。 编码的蛋白质具有TIR（Toll/IL-1受体）结构域。 IL-1RA由角膜上皮细胞、单核细胞、嗜中性粒细胞、巨噬细胞和成纤维细胞产生。 它是一种天然存在的炎症抑制蛋白。 重组人IL-1RA是由153个氨基酸残基组成的17.2kDa蛋白质。
Research Area: IMMUNO AND CKS
The interleukin-1 receptor antagonist (IL-1Ra) is part of the IL-1 family and binds to IL-1 receptors without triggering any intracellular response. IL-1Ra, produced by hepatic cells, exhibits characteristics of an acute phase protein. Endogenous IL-1Ra is generated in various experimental animal models of disease, as well as in human autoimmune and chronic inflammatory conditions.
The interleukin-1 receptor antagonist (IL-1Ra) is part of the IL-1 family and binds to IL-1 receptors without triggering any intracellular response. IL-1Ra, produced by hepatic cells, exhibits characteristics of an acute phase protein. Endogenous IL-1Ra is generated in various experimental animal models of disease, as well as in human autoimmune and chronic inflammatory conditions.
應用
IL-1Ra human has been used as an IL1 antagonist to block the signaling from the IL1 receptor and verify that IL1 signaling is responsible for invasiveness in CD133-expressing cells. It has also been used as a control in sandwich enzyme-linked immunosorbent assay (ELISA) to measure protein levels.
生化／生理作用
白细胞介素-1受体拮抗剂（IL-1RA）可通过竞争性阻断与其I型和II型受体的结合来抑制IL-1α（白细胞介素1 α）和IL-1β （白细胞介素1 β）的活性。 在治疗上，IL-1RA可以帮助治疗败血症、类风湿性关节炎、慢性髓性白血病、哮喘、牛皮癣和炎性肠病。 在HIV-1（人免疫缺陷病毒1）感染的树突细胞中观察到IL-1RA的低表达。
The interleukin-1 receptor antagonist (IL-1Ra) functions as a specific and selective competitive inhibitor of IL-1R1, binding to the receptor with high affinity.
序列
MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
外觀
由5mM Tris、pH 8.0 + 25 mM NaCl的溶液冻干而得。
重構
打开前离心小瓶。在水中复原至0.1-1.0mg/ml的浓度。不要涡旋。该溶液可在2-8°C条件下储存长达1周的时间。对于长期储存，建议在含有载体蛋白的缓冲液中进一步稀释（示例0.1% BSA），并在-20°C至-80°C条件下储存在工作等分试样中。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Alice Nomura et al.
Molecular cancer research : MCR, 16(1), 162-172 (2017-10-04)
Tumor-initiating cells (TIC) have been implicated in pancreatic tumor initiation, progression, and metastasis. Among different markers that define this cell population within the tumor, the CD133
The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1 beta production in human monocytes and neutrophils.
Jenkins JK
Lymphokine and Cytokine Research, 13, 47-54 (1994)
Identification of critical regions within the TIR domain of IL-1 receptor type I.
Radons J
The International Journal of Biochemistry & Cell Biology, 68, 15-20 (2015)
Association between interleukin-1 receptor antagonist (IL-1ra) gene polymorphism and early and late-onset psoriasis.
Tarlow JK
British Journal of Dermatology, 136, 147-148 (1997)
Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.
Nakki A
BMC Medical Genetics, 11, 10-10 (2010)
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