SML3388

Vortioxetine hydrobromide

≥98% (HPLC)

• 别名: 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine hydrobromide, Lu AA21004 HBr, Lu AA21004 hydrobromide, Vortioxetine HBr
• 经验公式（希尔记法）: C₁₈H₂₂N₂S·HBr
• CAS号: 960203-27-4
• 分子量: 379.36
• MDL號碼: MFCD22383961
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C
• InChI: 1S/C18H22N2S.BrH/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20;/h3-8,13,19H,9-12H2,1-2H3;1H
• InChI 密鑰: VNGRUFUIHGGOOM-UHFFFAOYSA-N

说明

生化／生理作用

Vortioxetine (Lu AA21004) is an orally active, multimodal serotonergic compound with high affinity toward human 5-HT1A (Ki = 15 nM), 5-HT1B (Ki = 33 nM), 5-HT1D (Ki = 54 nM), 5-HT3A (Ki = 3.7 nM), 5-HT7 (Ki = 19 nM), noradrenergic β1 (Ki = 46 nM) receptors, and serotonin (5-HT) transporter (SERT Ki = 1.6 nM). Vortioxetine exhibits in vivo psychotropic efficacy by exerting antagonist activity against 5-HT-1D/3A/7, agonist activity on 5-HT1A, partial agonist activity on 5-HT1B, as well as potent SERT inhibitory activity.

安全信息

• 象形圖: GHS08,GHS09
• 訊號詞: Warning
• 危險聲明: H361d,H373,H410
• 防範說明: P202 - P260 - P273 - P280 - P308 + P313 - P391
• 危險分類: Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2
• 標靶器官: Kidney
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable