SML3362

YM-244769 dihydrochloride

≥98% (HPLC)

• 别名: N-​[(3-​Aminophenyl)​methyl]​-​6-​[4-​[(3-​fluorophenyl)​methoxy]​phenoxy]​-3-​pyridinecarboxamide dihydrochloride, N-(3-Aminobenzyl)-6-{4-[3-fluorobenzyl)oxy]phenoxy} nicotinamide dihydrochloride
• 经验公式（希尔记法）: C₂₆H₂₂FN₃O₃·2HCl
• CAS号: 1780390-65-9
• 分子量: 516.39
• MDL號碼: MFCD28160863
• 分類程式碼代碼: 51111800
• 分類程式碼代碼: 12352200
• NACRES: NA.21

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to pink
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: -10 to -25°C
• SMILES 字串: O=C(C1=CC=C(OC2=CC=C(OCC3=CC=CC(F)=C3)C=C2)N=C1)NCC4=CC=CC(N)=C4
• InChI: 1S/C26H22FN3O3/c27-21-5-1-4-19(13-21)17-32-23-8-10-24(11-9-23)33-25-12-7-20(16-29-25)26(31)30-15-18-3-2-6-22(28)14-18/h1-14,16H,15,17,28H2,(H,30,31)
• InChI 密鑰: JZMLHJRKSJXARY-UHFFFAOYSA-N

说明

生化／生理作用

Potent and selective inhibitor of Na+/Ca2+ exchange (NCX) acting preferentially at NCX3

YM-244769 hydrochloride is a potent and selective inhibitor of Na+/Ca2+ exchange (NCX) acting preferentially at NCX3. It inhibits the Ca2+ entry mode of NCX more potently than the Ca2+ exit mode. YM-244769 exhibits protection in various hypoxic/ischemic cell injury models with low cell toxicity.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable