SML3306

BAY-390

≥98% (HPLC)

• 别名: (1R,2R)-2-(4-Fluorophenylamino)-1-(trifluoromethyl)cyclohexanol, BAY 390, BAY390
• 经验公式（希尔记法）: C₁₃H₁₅F₄NO
• CAS号: 2741956-55-6
• 分子量: 277.26
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: oil
• 顏色: yellow to orange
• 儲存溫度: 2-8°C
• SMILES 字串: FC1=CC=C(C=C1)N[C@H]2[C@@](C(F)(F)F)(CCCC2)O

说明

生化／生理作用

BAY-390 is an orally active, potent and selective TRPA1 inhibitor (cellular Ca++ influx IC50 in nM by FLIPR = 16/hu, 19/monkey, 63/rat, 68/guinea pig, 73/mu, 81/dog; IC50 = 5.6 µM/hTRPC5, >25 µM/human TRPV1/4, TRPC3/6, KCNK9 (TASK-3), CACNA1H (Cav3.2)) that shows in vivo efficacy in animal models of inflammatory pain (30 or 90 mg/kg mice, p.o.) and neurogenic pain (30 or 90 mg/kg rats, b.i.d. p.o.).

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable