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Merck

SML2573

Sigma-Aldrich

MitoCDNB

≥98% (HPLC)

别名:

[4-(5’-Chloro-2’,4’-dinitrophenylamino)but-1-yl]triphenylphosphonium methanosulfonate

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About This Item

经验公式(希尔记法):
C29H29ClN3O7PS
分子量:
630.05
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to very dark brown

溶解度

H2O: 2 mg/mL, clear (warmed)

儲存溫度

2-8°C

生化/生理作用

MitoCDNB is a mitochondrially selective inactivator of mitochondrial thiol redox homeostasis in isolated cells and in vivo. MitoCDNB selectively depletes the mitochondrial reduced glutathione (GSH) pool by formation of MitoGSDNB and dramatically increasing absorbance at 328 nm. It directly inhibits mitochondrial thioredoxin TrxR2 and peroxiredoxin 3.

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Lee M Booty et al.
Cell chemical biology, 26(3), 449-461 (2019-02-05)
Mitochondrial glutathione (GSH) and thioredoxin (Trx) systems function independently of the rest of the cell. While maintenance of mitochondrial thiol redox state is thought vital for cell survival, this was not testable due to the difficulty of manipulating the organelle's

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