SML2392
DREADD Agonist 21 dihydrochloride
≥98% (HPLC), powder, DREADD agonist
别名:
11-(1-piperazinyl)-5H-Dibenzo[b,e][1,4]diazepine dihydrochloride, 11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine; 11-Piperazinyldibenzo[b,e][1,4]diazepine dihydrochloride, Compound 21 dihydrochloride
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About This Item
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产品名称
DREADD Agonist 21 dihydrochloride, ≥98% (HPLC)
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
yellow to brown
溶解度
H2O: 2 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
C1(C=CC=C2)=C2C(N3CCNCC3)=NC(C=CC=C4)=C4N1
InChI
1S/C17H18N4/c1-2-6-14-13(5-1)17(21-11-9-18-10-12-21)20-16-8-4-3-7-15(16)19-14/h1-8,18-19H,9-12H2
InChI 密鑰
JCBYXNSOLUVGTF-UHFFFAOYSA-N
生化／生理作用
Compound 21 is a potent designer drug with full agonist activity toward human hM3Dq (EC50 = 1.7 nM by cell-based Ca2+ mobilization assay), a human M3 muscarinic receptor (M3R)-based Gq (M3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs), displaying little activity toward muscarinic acetylcholine receptor M3 (30% M3 activation at 10 μM) and reduced affinity toward H1, 5HT2A, 5HT2C, α1A receptor (fold selectivity = 3.5, 40, 100, 165, respectively). Note: the DREADD hM3Dq exhibits M3 biological activity, but is insensitive to the endogenous ligand acetylcholine (ACh).
Potent designer drug with selective agonist activity for human M3Dq (hM3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs).
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Xin Chen et al.
ACS chemical neuroscience, 6(3), 476-484 (2015-01-15)
Over the past decade, two independent technologies have emerged and been widely adopted by the neuroscience community for remotely controlling neuronal activity: optogenetics which utilize engineered channelrhodopsin and other opsins, and chemogenetics which utilize engineered G protein-coupled receptors (Designer Receptors
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