推荐产品
product name
盐酸氯氮平N-氧化物, ≥98% (HPLC), Water soluble Clozapine N-oxide
生物源
synthetic
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
溶解度
DMSO: 40 mg/mL
water: 40 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
SMILES 字串
ClC1=CC2=C(NC(C=CC=C3)=C3C(N4CC[N+]([O-])(C)CC4)=N2)C=C1.[xHCl]
InChI
1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChI 密鑰
OGUCZBIQSYYWEF-UHFFFAOYSA-N
一般說明
氯氮平n -氧化物盐酸盐是氯氮平n -氧化物(CNO)的一种水溶性形式(Sigma cat# C0832)。CNO是非典型抗精神病药物氯氮平的一种惰性代谢产物。CNO是设计药物特异激活的化学遗传设计受体(DREADD)中工程Gq蛋白偶联受体(GPCR)配体。DREADD的典型应用是测试，增强神经元和非神经元细胞的神经元放电和激活Gq信号。
通过使用细胞类型特异性启动子驱动DREADD表达可以实现对细胞群体的选择性靶向，并通过重组系统进一步控制该启动子的表达。DREADD对内源性配体的亲和力较低，其组成活性较低，但可能被CNO等合成化合物激活。
低nM浓度的CNO激活了DREADD系统，并调动了细胞内钙。当小鼠和大鼠按推荐剂量（一般为0.1-3 mg/kg）给药时，CNO在药理学和行为学上似乎是惰性的。CNO通常通过注射给药，但也可以混合到食物或饮用水中。
通过使用细胞类型特异性启动子驱动DREADD表达可以实现对细胞群体的选择性靶向，并通过重组系统进一步控制该启动子的表达。DREADD对内源性配体的亲和力较低，其组成活性较低，但可能被CNO等合成化合物激活。
低nM浓度的CNO激活了DREADD系统，并调动了细胞内钙。当小鼠和大鼠按推荐剂量（一般为0.1-3 mg/kg）给药时，CNO在药理学和行为学上似乎是惰性的。CNO通常通过注射给药，但也可以混合到食物或饮用水中。
其他說明
This is not a pharmaceutical grade product.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - STOT SE 3
標靶器官
Central nervous system
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Michael J Krashes et al.
The Journal of clinical investigation, 121(4), 1424-1428 (2011-03-03)
Several different neuronal populations are involved in regulating energy homeostasis. Among these, agouti-related protein (AgRP) neurons are thought to promote feeding and weight gain; however, the evidence supporting this view is incomplete. Using designer receptors exclusively activated by designer drugs
Blaine N Armbruster et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(12), 5163-5168 (2007-03-16)
We evolved muscarinic receptors in yeast to generate a family of G protein-coupled receptors (GPCRs) that are activated solely by a pharmacologically inert drug-like and bioavailable compound (clozapine-N-oxide). Subsequent screening in human cell lines facilitated the creation of a family
Daniel J Urban et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41(5), 1404-1415 (2015-09-19)
Elucidating how the brain's serotonergic network mediates diverse behavioral actions over both relatively short (minutes-hours) and long period of time (days-weeks) remains a major challenge for neuroscience. Our relative ignorance is largely due to the lack of technologies with robustness
Susan M Ferguson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(28), 11668-11676 (2013-07-12)
The dorsal striatum has been implicated in reward-based decision making, but the role played by specific striatal circuits in these processes is essentially unknown. Using cell phenotype-specific viral vectors to express engineered G-protein-coupled DREADD (designer receptors exclusively activated by designer
Susan M Ferguson et al.
Nature neuroscience, 14(1), 22-24 (2010-12-07)
Dorsal striatum is important for the development of drug addiction; however, a precise understanding of the roles of striatopallidal (indirect) and striatonigral (direct) pathway neurons in regulating behaviors remains elusive. Using viral-mediated expression of an engineered G protein-coupled receptor (hM(4)D)
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