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Merck
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文件

SML2160

Sigma-Aldrich

R-568 盐酸盐

≥95% (HPLC)

别名:

2-氯-N-[（（1R）-1-（3-甲氧基苯基）乙基]-苯丙胺盐酸盐（1：1）, KRN 568盐酸盐, NPS-R 568盐酸盐, R 568盐酸盐, Tecalcet盐酸, 盐酸降钙素

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About This Item

经验公式（希尔记法）:
C18H22ClNO · HCl
CAS号:
177172-49-5
分子量:
340.29
MDL號碼:
MFCD16038895
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥95% (HPLC)

形狀

powder

光學活性

[α]/D +35 to +40°, c = 0.5 in chloroform-d

儲存條件

desiccated

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear (warmed)

儲存溫度

2-8°C

SMILES 字串

C[C@@H](NCCCC1=C(C=CC=C1)Cl)C2=CC=CC(OC)=C2.Cl

InChI

1S/C18H22ClNO.ClH/c1-14(16-8-5-10-17(13-16)21-2)20-12-6-9-15-7-3-4-11-18(15)19;/h3-5,7-8,10-11,13-14,20H,6,9,12H2,1-2H3;1H/t14-;/m1./s1

InChI 密鑰

YJXUXANREVNZLH-PFEQFJNWSA-N

生化／生理作用

R-568 是钙敏感受体（CaSR）的正向别构调节剂，可增加对细胞外 Ca2+ 激活的敏感性。在大鼠中，口服 R-568 会降低 PTH 和 Ca2+ 的血浆水平，而在较高剂量时会降低降钙素的血浆水平。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Jenny Ying Lin Lu et al.
The Journal of pharmacology and experimental therapeutics, 331(3), 775-786 (2009-09-18)
Over 257 mutations in the human calcium-sensing receptor (hCaSR) gene have been reported. Heterozygous inactivating mutations can result in familial hypocalciuric hypercalcemia (FHH), whereas homozygous inactivating mutations can cause life-threatening neonatal severe hyperparathyroidism (NSHPT). Activating mutations in the hCaSR can
Fanny Bery et al.
Cancers, 12(4) (2020-04-08)
The mechanisms underlying neuroendocrine (NE) differentiation in prostate cancer (PCa) remain mostly uncharacterized. Since a deregulated calcium homeostasis has been reported in neuroendocrine prostate cancer (NEPC), we explored herein the link between NE differentiation and the calcium-sensing receptor (CaSR). CaSR
Asuka Masumoto et al.
Journal of atherosclerosis and thrombosis, 24(7), 716-724 (2016-11-15)
Vascular calcification (VC) is a risk factor of cardiovascular and all-cause mortality in patients with chronic kidney disease (CKD). CKD-mineral and bone metabolism disorder is an important problem in patients with renal failure. Abnormal levels of serum phosphate and calcium
Abhishek Aggarwal et al.
Biochimica et biophysica acta, 1853(9), 2158-2167 (2015-02-24)
The inverse correlation between dietary calcium intake and the risk of colorectal cancer (CRC) is well known, but poorly understood. Expression of the calcium-sensing receptor (CaSR), a calcium-binding G protein-coupled receptor is downregulated in CRC leading us to hypothesize that

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