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化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 5 mg/mL, clear (warmed)
儲存溫度
2-8°C
InChI
1S/C12H4Cl6O4S/c13-3-1-5(15)9(19)11(7(3)17)23(21,22)12-8(18)4(14)2-6(16)10(12)20/h1-2,19-20H
InChI 密鑰
AKUKHICVNCCQHN-UHFFFAOYSA-N
應用
p38 MAP激酶抑制剂IV被用于替代p38α激酶的激活,以检测HOXB7是否通过AKT / MAPK信号参与转移迁移和增殖过程。
生化/生理作用
p38 MAP激酶抑制剂IV是p38α/βMAPK的ATP竞争性抑制剂,p38α和p38β的 MAPK IC50值分别为130 nM和550 nM。在1μM时,它对p38γ/σ,ERK1/2和JNK1/2/3的活性浓度、抑制率≤23%。在抑制LPS诱导hPBMC释放IL-1β方面,它比SB 203580更有效(100%vs、100μM抑制剂的抑制毒性50%)。最近的一项研究表明,p38 MAP激酶抑制剂IV可以持续显着着地增强体细胞的重编程和iPS细胞生成。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
其他客户在看
Oncotarget, 8(1), 1247-1261 (2016-12-03)
Increased expression of HOXB7 has been reported to correlate with the progression in many cancers. However, the specific mechanism by which it promotes the evolution of gastric cancer (GC) is poorly understood.In this study, we sought to investigate the role
Particle and fibre toxicology, 20(1), 2-2 (2023-01-10)
Polypropylene (PP) is used in various products such as disposable containers, spoons, and automobile parts. The disposable masks used for COVID-19 prevention mainly comprise PP, and the disposal of such masks is concerning because of the potential environmental pollution. Recent
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