推荐产品
产品名称
BAM15, ≥98% (HPLC)
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
FC(C=CC=C1)=C1NC2=NC3=NON=C3N=C2NC4=CC=CC=C4F
InChI
1S/C16H10F2N6O/c17-9-5-1-3-7-11(9)19-13-14(20-12-8-4-2-6-10(12)18)22-16-15(21-13)23-25-24-16/h1-8H,(H,19,21,23)(H,20,22,24)
InChI 密鑰
OEGJBRZAJRPPHL-UHFFFAOYSA-N
生化／生理作用
BAM15 可增加线粒体呼吸速率，与其他质子化解偶联剂如羰基氰化物 p -三氟甲氧基苯腙相比，其细胞毒性也较小。致癌 MAPK（丝裂原活化蛋白激酶）信号传导受阻导致 BAM15 诱导线粒体凋亡途径激活。
BAM15 是一种细胞渗透剂和强效的线粒体氧化磷酸化解偶联剂，不会使质膜去极化。BAM15 保护小鼠急性肾缺血再灌注损伤。
BAM15 是一种细胞渗透剂和有效的线粒体氧化磷酸化解偶联剂。
危險聲明
防範說明
危險分類
Aquatic Chronic 4
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition.
Serasinghe M N, et al.
Cell Death & Disease, 9(2), 29-29 (2018)
Brandon M Kenwood et al.
Molecular metabolism, 3(2), 114-123 (2014-03-19)
Dysregulation of oxidative phosphorylation is associated with increased mitochondrial reactive oxygen species production and some of the most prevalent human diseases including obesity, cancer, diabetes, neurodegeneration, and heart disease. Chemical 'mitochondrial uncouplers' are lipophilic weak acids that transport protons into
Brandon M Kenwood et al.
Bioorganic & medicinal chemistry letters, 25(21), 4858-4861 (2015-06-30)
Chemical mitochondrial uncouplers are lipophilic weak acids that transport protons into the mitochondrial matrix via a pathway that is independent of ATP synthase, thereby uncoupling nutrient oxidation from ATP production. These uncouplers have potential for the treatment of diseases such
Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.
Kenwood B M, et al.
Molecular Metabolism, 3(2), 114-123 (2014)
Keshav Kooragayala et al.
Investigative ophthalmology & visual science, 56(13), 8428-8436 (2016-01-10)
Cell death in neurodegeneration occurs at the convergence of diverse metabolic pathways. In the retina, a common underlying mechanism involves mitochondrial dysfunction since photoreceptor homeostasis and survival are highly susceptible to altered aerobic energy metabolism. We sought to develop an
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