SML1607

Lesinurad

≥98% (HPLC)

• 别名: 2-[[5-Bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic acid, RDEA 594
• 经验公式（希尔记法）: C₁₇H₁₄BrN₃O₂S
• CAS号: 878672-00-5
• 分子量: 404.28
• MDL號碼: MFCD22572730
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825493
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 25 mg/mL, clear
• 儲存溫度: −20°C
• SMILES 字串: BrC1=NN=C(SCC(O)=O)N1C2=C3C(C=CC=C3)=C(C4CC4)C=C2
• InChI: 1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23)
• InChI 密鑰: FGQFOYHRJSUHMR-UHFFFAOYSA-N
• 基因資訊: human ... SLC22A12(116085)

说明

生化／生理作用

Lesinurad is a selective inhibitor of Urate transporter 1 (URAT1), a urate-anion exchanger which is responsible for the majority of uric acid reabsorption from the renal tubular lumen. Lesinurad thus reduces serum uric acid levels. Lesinurad has been approved for use in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout.

Lesinurad is a selective inhibitor of Urate transporter 1 (URAT1).

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable